One-step melt synthesis of water-soluble, photoluminescent, surface-oxidized silicon nanoparticles for cellular imaging applications

Beth A. Manhat, Anna L. Brown, Labe A. Black, J. B Alexander Ross, Katye Fichter, Tothu (Tania) Vu, Erik Richman, Andrea M. Goforth

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We have developed a versatile, one-step melt synthesis of water-soluble, highly emissive silicon nanoparticles using bifunctional, low-melting solids (such as glutaric acid) as reaction media. Characterization through transmission electron microscopy, selected area electron diffraction, X-ray photoelectron spectroscopy, and Raman spectroscopy shows that the one-step melt synthesis produces nanoscale Si cores surrounded by a silicon oxide shell. Analysis of the nanoparticle surface using FT-IR, zeta potential, and gel electrophoresis indicates that the bifunctional ligand used in the one-step synthesis is grafted onto the nanoparticle, which allows for tuning of the particle surface charge, solubility, and functionality. Photoluminescence spectra of the as-prepared glutaric acid-synthesized silicon nanoparticles show an intense blue-green emission with a short (ns) lifetime suitable for biological imaging. These nanoparticles are found to be stable in biological media and have been used to examine cellular uptake and distribution in live N2a cells.

Original languageEnglish (US)
Pages (from-to)2407-2418
Number of pages12
JournalChemistry of Materials
Volume23
Issue number9
DOIs
StatePublished - May 10 2011

Fingerprint

Silicon
Nanoparticles
Imaging techniques
Water
Acids
Silicon oxides
Zeta potential
Surface charge
Electrophoresis
Electron diffraction
Raman spectroscopy
Photoluminescence
Melting
Gels
X ray photoelectron spectroscopy
Solubility
Tuning
Ligands
Transmission electron microscopy
glutaric acid

Keywords

  • aqueous suspension
  • cellular imaging
  • luminescence
  • melt synthesis
  • nanoparticles
  • one-step synthesis
  • optical spectroscopy
  • quantum yield
  • Si nanoparticles
  • silicon
  • surface modification
  • surface oxide

ASJC Scopus subject areas

  • Materials Chemistry
  • Chemical Engineering(all)
  • Chemistry(all)

Cite this

One-step melt synthesis of water-soluble, photoluminescent, surface-oxidized silicon nanoparticles for cellular imaging applications. / Manhat, Beth A.; Brown, Anna L.; Black, Labe A.; Ross, J. B Alexander; Fichter, Katye; Vu, Tothu (Tania); Richman, Erik; Goforth, Andrea M.

In: Chemistry of Materials, Vol. 23, No. 9, 10.05.2011, p. 2407-2418.

Research output: Contribution to journalArticle

Manhat, Beth A. ; Brown, Anna L. ; Black, Labe A. ; Ross, J. B Alexander ; Fichter, Katye ; Vu, Tothu (Tania) ; Richman, Erik ; Goforth, Andrea M. / One-step melt synthesis of water-soluble, photoluminescent, surface-oxidized silicon nanoparticles for cellular imaging applications. In: Chemistry of Materials. 2011 ; Vol. 23, No. 9. pp. 2407-2418.
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