One percent tenofovir applied topically to humanized BLT Mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the blt model for evaluation of new microbicide candidates

Paul W. Denton, Florence Othieno, Francisco Martinez-Torres, Wei Zou, John F. Krisko, Elisa Fleming, Sima Zein, Daniel A. Powell, Angela Wahl, Youn Tae Kwak, Brett D. Welch, Michael S. Kay, Deborah A. Payne, Philippe Gallay, Ettore Appella, Jacob D. Estes, Min Lu, J. Victor Garcia

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