On translational regulation and EMT

Valentina Evdokimova, Cristina E. Tognon, Poul H.B. Sorensen

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations

Abstract

Translational regulation is increasingly recognized as a critical mediator of gene expression. It endows cells with the ability to decide when a particular protein is expressed, thereby ensuring proper and prompt cellular responses to environmental cues. This ability to reprogram protein synthesis and to permit the translation of the respective regulatory messages is particularly important in complex changing environments, including embryonic development, wound healing and environmental stress. Not surprisingly, mistakes in this process can lead to cancer. This review will focus on the mechanisms of translational control operating in normal and cancer cells. We discuss the possibility that progression of primary epithelial tumors into a motile mesenchymal-like phenotype during the invasive phase of metastasis is driven, in part, by a switch from cap-dependent to cap-independent translation.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalSeminars in Cancer Biology
Volume22
Issue number5-6
DOIs
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • Cancer
  • Epithelial-to-mesenchymal transition
  • Metastasis
  • Translation
  • YB-1

ASJC Scopus subject areas

  • Cancer Research

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