Abstract
Background: Although fatty acid intake has been associated with risk of coronary disease events, the association between blood omega-6 and trans fatty acids (FAs) at the time of an acute coronary syndrome (ACS) is unknown. Methods: The relationship of blood FA composition to ACS was analyzed in 768 incident cases and 768 controls (matched on age, sex, and race). Results: Compared to controls, ACS cases' blood cell membrane content of linoleic acid was 13% lower (P <.0001); arachidonic acid was 3.6% higher (P <.001); the trans isomer of oleic acid was 13.3% higher (P <.0001); and the trans-trans isomer of linoleic acid was 13.3% higher (P = .003). In multivariable analyses, a 1-SD decrease in linoleic acid was associated with >3 times the odds for being a case (odds ratio [OR] 3.23, 95% confidence interval [CI] 2.63-4.17). The relationship of arachidonic acid to ACS was U shaped; compared to the first quartile of arachidonic acid, the ORs for case status in the second, third, and fourth quartiles were 0.73 (95% CI 0.47-1.13), 0.65 (95% CI 0.41-1.04), and 2.32 (95% CI 1.39-3.90), respectively. The OR for a 1-SD increase in trans oleic acid was 1.24 (95% CI 1.06-1.45), and for trans-trans linoleic acid, 1.1 (95% CI 0.93-1.30). All associations were independent of membrane omega-3 FA content. Conclusions: High blood levels of linoleic acid but low levels of trans oleic acid are inversely associated with ACS. The relationship of arachidonic acid to ACS appears more complex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1117-1123 |
| Number of pages | 7 |
| Journal | American Heart Journal |
| Volume | 156 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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Omega-6 and trans fatty acids in blood cell membranes : A risk factor for acute coronary syndromes? / Block, Robert C.; Harris, William; Reid, Kimberly J.; Spertus, John A.
In: American Heart Journal, Vol. 156, No. 6, 12.2008, p. 1117-1123.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Omega-6 and trans fatty acids in blood cell membranes
T2 - A risk factor for acute coronary syndromes?
AU - Block, Robert C.
AU - Harris, William
AU - Reid, Kimberly J.
AU - Spertus, John A.
PY - 2008/12
Y1 - 2008/12
N2 - Background: Although fatty acid intake has been associated with risk of coronary disease events, the association between blood omega-6 and trans fatty acids (FAs) at the time of an acute coronary syndrome (ACS) is unknown. Methods: The relationship of blood FA composition to ACS was analyzed in 768 incident cases and 768 controls (matched on age, sex, and race). Results: Compared to controls, ACS cases' blood cell membrane content of linoleic acid was 13% lower (P <.0001); arachidonic acid was 3.6% higher (P <.001); the trans isomer of oleic acid was 13.3% higher (P <.0001); and the trans-trans isomer of linoleic acid was 13.3% higher (P = .003). In multivariable analyses, a 1-SD decrease in linoleic acid was associated with >3 times the odds for being a case (odds ratio [OR] 3.23, 95% confidence interval [CI] 2.63-4.17). The relationship of arachidonic acid to ACS was U shaped; compared to the first quartile of arachidonic acid, the ORs for case status in the second, third, and fourth quartiles were 0.73 (95% CI 0.47-1.13), 0.65 (95% CI 0.41-1.04), and 2.32 (95% CI 1.39-3.90), respectively. The OR for a 1-SD increase in trans oleic acid was 1.24 (95% CI 1.06-1.45), and for trans-trans linoleic acid, 1.1 (95% CI 0.93-1.30). All associations were independent of membrane omega-3 FA content. Conclusions: High blood levels of linoleic acid but low levels of trans oleic acid are inversely associated with ACS. The relationship of arachidonic acid to ACS appears more complex.
AB - Background: Although fatty acid intake has been associated with risk of coronary disease events, the association between blood omega-6 and trans fatty acids (FAs) at the time of an acute coronary syndrome (ACS) is unknown. Methods: The relationship of blood FA composition to ACS was analyzed in 768 incident cases and 768 controls (matched on age, sex, and race). Results: Compared to controls, ACS cases' blood cell membrane content of linoleic acid was 13% lower (P <.0001); arachidonic acid was 3.6% higher (P <.001); the trans isomer of oleic acid was 13.3% higher (P <.0001); and the trans-trans isomer of linoleic acid was 13.3% higher (P = .003). In multivariable analyses, a 1-SD decrease in linoleic acid was associated with >3 times the odds for being a case (odds ratio [OR] 3.23, 95% confidence interval [CI] 2.63-4.17). The relationship of arachidonic acid to ACS was U shaped; compared to the first quartile of arachidonic acid, the ORs for case status in the second, third, and fourth quartiles were 0.73 (95% CI 0.47-1.13), 0.65 (95% CI 0.41-1.04), and 2.32 (95% CI 1.39-3.90), respectively. The OR for a 1-SD increase in trans oleic acid was 1.24 (95% CI 1.06-1.45), and for trans-trans linoleic acid, 1.1 (95% CI 0.93-1.30). All associations were independent of membrane omega-3 FA content. Conclusions: High blood levels of linoleic acid but low levels of trans oleic acid are inversely associated with ACS. The relationship of arachidonic acid to ACS appears more complex.
UR - http://www.scopus.com/inward/record.url?scp=56349113182&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=56349113182&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2008.07.014
DO - 10.1016/j.ahj.2008.07.014
M3 - Article
VL - 156
SP - 1117
EP - 1123
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 6
ER -