Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation

William Harris, Scott A. Sands, Sheryl L. Windsor, Hakim A. Ali, Tracy L. Stevens, Anthony Magalski, Charles B. Porter, A. Michael Borkon

Research output: Contribution to journalArticle

250 Citations (Scopus)

Abstract

Background - Omega-3 fatty acids (FAs) appear to reduce the risk of sudden death from myocardial infarction. This reduction is believed to occur via the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into the myocardium itself, altering the dynamics of sodium and calcium channel function. The extent of incorporation has not been determined in humans. Methods and Results - We first determined the correlation between red blood cell (RBC) and cardiac omega-3 FA levels in 20 heart transplant recipients. We then examined the effects of 6 months of omega-3 FA supplementation (1 g/d) on the FA composition of human cardiac and buccal tissue, RBCs, and plasma lipids in 25 other patients. Cardiac and RBC EPA+DHA levels were highly correlated (r=0.82, P

Original languageEnglish (US)
Pages (from-to)1645-1649
Number of pages5
JournalCirculation
Volume110
Issue number12
DOIs
StatePublished - Sep 21 2004
Externally publishedYes

Fingerprint

Omega-3 Fatty Acids
Heart Transplantation
Eicosapentaenoic Acid
Docosahexaenoic Acids
Erythrocytes
Biopsy
Sodium Channels
Cheek
Calcium Channels
Sudden Death
Myocardium
Fatty Acids
Myocardial Infarction
Lipids

Keywords

  • Biopsy
  • Fatty acids, omega-3
  • Fish oils
  • Myocardium

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Harris, W., Sands, S. A., Windsor, S. L., Ali, H. A., Stevens, T. L., Magalski, A., ... Borkon, A. M. (2004). Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation. Circulation, 110(12), 1645-1649. https://doi.org/10.1161/01.CIR.0000142292.10048.B2

Omega-3 fatty acids in cardiac biopsies from heart transplantation patients : Correlation with erythrocytes and response to supplementation. / Harris, William; Sands, Scott A.; Windsor, Sheryl L.; Ali, Hakim A.; Stevens, Tracy L.; Magalski, Anthony; Porter, Charles B.; Borkon, A. Michael.

In: Circulation, Vol. 110, No. 12, 21.09.2004, p. 1645-1649.

Research output: Contribution to journalArticle

Harris, W, Sands, SA, Windsor, SL, Ali, HA, Stevens, TL, Magalski, A, Porter, CB & Borkon, AM 2004, 'Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: Correlation with erythrocytes and response to supplementation', Circulation, vol. 110, no. 12, pp. 1645-1649. https://doi.org/10.1161/01.CIR.0000142292.10048.B2
Harris, William ; Sands, Scott A. ; Windsor, Sheryl L. ; Ali, Hakim A. ; Stevens, Tracy L. ; Magalski, Anthony ; Porter, Charles B. ; Borkon, A. Michael. / Omega-3 fatty acids in cardiac biopsies from heart transplantation patients : Correlation with erythrocytes and response to supplementation. In: Circulation. 2004 ; Vol. 110, No. 12. pp. 1645-1649.
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