Omega-3 Fatty Acids and Cardiovascular Disease Prevention

Thomas A. Barringer, William Harris

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Observational studies and early clinical trials indicated that long-chain n-3 fatty acids have a role in prevention of coronary heart disease, specifically fatal coronary heart disease. Results of recent trials have been inconsistent, although the study designs, patient populations, and n-3 doses have been quite different. Some studies have called into question whether there is any benefit from n-3 fatty acid therapy in patients who are receiving guideline-based treatment since their coronary event. Other recent trials suggest that certain patient subgroups, specifically those with diabetes or metabolic syndrome, may derive a significant benefit. Also, the only clinical trial to show a reduction in nonfatal coronary events used a higher n-3 fatty acid dose than used in the other studies, which raises the question of whether more is better for certain clinical outcomes. Only further research can resolve these questions.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalCurrent Nutrition Reports
Volume1
Issue number2
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

disease prevention
Omega-3 Fatty Acids
omega-3 fatty acids
cardiovascular diseases
Cardiovascular Diseases
Coronary Disease
clinical trials
Clinical Trials
metabolic syndrome
long chain fatty acids
observational studies
dosage
Observational Studies
diabetes
experimental design
Guidelines
therapeutics
Therapeutics
Research
Population

Keywords

  • Alpha Omega
  • Cardiovascular
  • Cardiovascular disease
  • Coronary heart disease
  • DART
  • DHA
  • EPA
  • GISSI-HF
  • GISSI-Prevenzione
  • Heart failure
  • JELIS
  • n-3 fatty acids
  • OMEGA
  • Omega-3 fatty acids
  • Prevention
  • Randomized controlled trial
  • SU.FOL.OM3

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Omega-3 Fatty Acids and Cardiovascular Disease Prevention. / Barringer, Thomas A.; Harris, William.

In: Current Nutrition Reports, Vol. 1, No. 2, 01.01.2012, p. 115-122.

Research output: Contribution to journalReview article

Barringer, Thomas A. ; Harris, William. / Omega-3 Fatty Acids and Cardiovascular Disease Prevention. In: Current Nutrition Reports. 2012 ; Vol. 1, No. 2. pp. 115-122.
@article{df59e368693c4e88ac248e9203183334,
title = "Omega-3 Fatty Acids and Cardiovascular Disease Prevention",
abstract = "Observational studies and early clinical trials indicated that long-chain n-3 fatty acids have a role in prevention of coronary heart disease, specifically fatal coronary heart disease. Results of recent trials have been inconsistent, although the study designs, patient populations, and n-3 doses have been quite different. Some studies have called into question whether there is any benefit from n-3 fatty acid therapy in patients who are receiving guideline-based treatment since their coronary event. Other recent trials suggest that certain patient subgroups, specifically those with diabetes or metabolic syndrome, may derive a significant benefit. Also, the only clinical trial to show a reduction in nonfatal coronary events used a higher n-3 fatty acid dose than used in the other studies, which raises the question of whether more is better for certain clinical outcomes. Only further research can resolve these questions.",
keywords = "Alpha Omega, Cardiovascular, Cardiovascular disease, Coronary heart disease, DART, DHA, EPA, GISSI-HF, GISSI-Prevenzione, Heart failure, JELIS, n-3 fatty acids, OMEGA, Omega-3 fatty acids, Prevention, Randomized controlled trial, SU.FOL.OM3",
author = "Barringer, {Thomas A.} and William Harris",
year = "2012",
month = "1",
day = "1",
doi = "10.1007/s13668-012-0011-5",
language = "English (US)",
volume = "1",
pages = "115--122",
journal = "Current Nutrition Reports",
issn = "2161-3311",
publisher = "Springer New York",
number = "2",

}

TY - JOUR

T1 - Omega-3 Fatty Acids and Cardiovascular Disease Prevention

AU - Barringer, Thomas A.

AU - Harris, William

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Observational studies and early clinical trials indicated that long-chain n-3 fatty acids have a role in prevention of coronary heart disease, specifically fatal coronary heart disease. Results of recent trials have been inconsistent, although the study designs, patient populations, and n-3 doses have been quite different. Some studies have called into question whether there is any benefit from n-3 fatty acid therapy in patients who are receiving guideline-based treatment since their coronary event. Other recent trials suggest that certain patient subgroups, specifically those with diabetes or metabolic syndrome, may derive a significant benefit. Also, the only clinical trial to show a reduction in nonfatal coronary events used a higher n-3 fatty acid dose than used in the other studies, which raises the question of whether more is better for certain clinical outcomes. Only further research can resolve these questions.

AB - Observational studies and early clinical trials indicated that long-chain n-3 fatty acids have a role in prevention of coronary heart disease, specifically fatal coronary heart disease. Results of recent trials have been inconsistent, although the study designs, patient populations, and n-3 doses have been quite different. Some studies have called into question whether there is any benefit from n-3 fatty acid therapy in patients who are receiving guideline-based treatment since their coronary event. Other recent trials suggest that certain patient subgroups, specifically those with diabetes or metabolic syndrome, may derive a significant benefit. Also, the only clinical trial to show a reduction in nonfatal coronary events used a higher n-3 fatty acid dose than used in the other studies, which raises the question of whether more is better for certain clinical outcomes. Only further research can resolve these questions.

KW - Alpha Omega

KW - Cardiovascular

KW - Cardiovascular disease

KW - Coronary heart disease

KW - DART

KW - DHA

KW - EPA

KW - GISSI-HF

KW - GISSI-Prevenzione

KW - Heart failure

KW - JELIS

KW - n-3 fatty acids

KW - OMEGA

KW - Omega-3 fatty acids

KW - Prevention

KW - Randomized controlled trial

KW - SU.FOL.OM3

UR - http://www.scopus.com/inward/record.url?scp=84889020125&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84889020125&partnerID=8YFLogxK

U2 - 10.1007/s13668-012-0011-5

DO - 10.1007/s13668-012-0011-5

M3 - Review article

AN - SCOPUS:84889020125

VL - 1

SP - 115

EP - 122

JO - Current Nutrition Reports

JF - Current Nutrition Reports

SN - 2161-3311

IS - 2

ER -