Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis,

L. Shinto; G. Marracci; S. Baldauf-Wagner; A. Strehlow; V. Yadav; L. Stuber; D. Bourdette

doi:10.1016/j.plefa.2008.12.001

Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis^,

L. Shinto, G. Marracci, S. Baldauf-Wagner, A. Strehlow, V. Yadav, L. Stuber, D. Bourdette

Neurology

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Objectives: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Quality of life, fatty acid levels, and safety were also evaluated. Materials and Methods: Ten participants with relapsing-remitting MS (RRMS) received omega-3 FA supplementation (9.6 g/day fish oil) in an open-label study. Participants were evaluated at four time points, baseline, after 1 month of omega-3 FA supplementation, after 3 months of omega-3 FA supplementation, and after a 3-month wash out. Results: Immune cell secretion of MMP-9 decreased by 58% after 3 months of omega-3 FA supplementation when compared with baseline levels (p<0.01). This effect was coupled with a significant increase in omega-3 FA levels in red blood cell membranes. Conclusions: Omega-3 FA significantly decreased MMP-9 levels in RRMS and may act as an immune-modulator that has potential therapeutic benefit in MS patients.

Original language	English (US)
Pages (from-to)	131-136
Number of pages	6
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	80
Issue number	2-3
DOIs	https://doi.org/10.1016/j.plefa.2008.12.001
State	Published - Feb 2009

Keywords

Matrix metalloproteinase
Multiple sclerosis
Omega-3 fatty acids

ASJC Scopus subject areas

Clinical Biochemistry
Cell Biology

Access to Document

10.1016/j.plefa.2008.12.001

Cite this

@article{25087c39d2494297bab066d99f6326d6,

title = "Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis,",

abstract = "Objectives: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Quality of life, fatty acid levels, and safety were also evaluated. Materials and Methods: Ten participants with relapsing-remitting MS (RRMS) received omega-3 FA supplementation (9.6 g/day fish oil) in an open-label study. Participants were evaluated at four time points, baseline, after 1 month of omega-3 FA supplementation, after 3 months of omega-3 FA supplementation, and after a 3-month wash out. Results: Immune cell secretion of MMP-9 decreased by 58% after 3 months of omega-3 FA supplementation when compared with baseline levels (p<0.01). This effect was coupled with a significant increase in omega-3 FA levels in red blood cell membranes. Conclusions: Omega-3 FA significantly decreased MMP-9 levels in RRMS and may act as an immune-modulator that has potential therapeutic benefit in MS patients.",

keywords = "Matrix metalloproteinase, Multiple sclerosis, Omega-3 fatty acids",

author = "L. Shinto and G. Marracci and S. Baldauf-Wagner and A. Strehlow and V. Yadav and L. Stuber and D. Bourdette",

note = "Funding Information: This research was funded by National Institutes of Health Grant P50 AT00066-01, the Department of Veterans Affairs, and the Nancy Davis Center Without Walls. The authors wish to thank Vital Nutrients, Middletown, CT, for supplying the fish oil concentrate. Funding Information: This research was support by the National Institutes of Health P50 AT00066-01, the Department of Veterans Affairs, and the Nancy Davis Center Without Walls. ",

year = "2009",

month = feb,

doi = "10.1016/j.plefa.2008.12.001",

language = "English (US)",

volume = "80",

pages = "131--136",

journal = "Prostaglandins Leukotrienes and Essential Fatty Acids",

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T1 - Omega-3 fatty acid supplementation decreases matrix metalloproteinase-9 production in relapsing-remitting multiple sclerosis,

AU - Shinto, L.

AU - Marracci, G.

AU - Baldauf-Wagner, S.

AU - Strehlow, A.

AU - Yadav, V.

AU - Stuber, L.

AU - Bourdette, D.

N1 - Funding Information: This research was funded by National Institutes of Health Grant P50 AT00066-01, the Department of Veterans Affairs, and the Nancy Davis Center Without Walls. The authors wish to thank Vital Nutrients, Middletown, CT, for supplying the fish oil concentrate. Funding Information: This research was support by the National Institutes of Health P50 AT00066-01, the Department of Veterans Affairs, and the Nancy Davis Center Without Walls.

PY - 2009/2

Y1 - 2009/2

N2 - Objectives: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Quality of life, fatty acid levels, and safety were also evaluated. Materials and Methods: Ten participants with relapsing-remitting MS (RRMS) received omega-3 FA supplementation (9.6 g/day fish oil) in an open-label study. Participants were evaluated at four time points, baseline, after 1 month of omega-3 FA supplementation, after 3 months of omega-3 FA supplementation, and after a 3-month wash out. Results: Immune cell secretion of MMP-9 decreased by 58% after 3 months of omega-3 FA supplementation when compared with baseline levels (p<0.01). This effect was coupled with a significant increase in omega-3 FA levels in red blood cell membranes. Conclusions: Omega-3 FA significantly decreased MMP-9 levels in RRMS and may act as an immune-modulator that has potential therapeutic benefit in MS patients.

AB - Objectives: The primary objective was to evaluate the effect of omega-3 fatty acids (omega-3 FA) on matrix metalloproteinase-9 (MMP-9) production by immune cells in multiple sclerosis (MS). Quality of life, fatty acid levels, and safety were also evaluated. Materials and Methods: Ten participants with relapsing-remitting MS (RRMS) received omega-3 FA supplementation (9.6 g/day fish oil) in an open-label study. Participants were evaluated at four time points, baseline, after 1 month of omega-3 FA supplementation, after 3 months of omega-3 FA supplementation, and after a 3-month wash out. Results: Immune cell secretion of MMP-9 decreased by 58% after 3 months of omega-3 FA supplementation when compared with baseline levels (p<0.01). This effect was coupled with a significant increase in omega-3 FA levels in red blood cell membranes. Conclusions: Omega-3 FA significantly decreased MMP-9 levels in RRMS and may act as an immune-modulator that has potential therapeutic benefit in MS patients.

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