Omega-3 fatty acid deficiency and cardiovascular disease

Thomas A. Barringer, William S. Harris

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Observational studies and early clinical trials indicated that long-chain n-3 fatty acids have a role in prevention of coronary heart disease (CHD), specifically fatal CHD. Results of recent trials have been mixed, although the study designs, patient populations, and n-3 doses have been quite different. Some studies have called into question whether there is any benefit from n-3 fatty acid therapy in patients who are receiving guideline-based treatment since their coronary event. Other recent trials suggest that certain patient subgroups, specifically those with diabetes or CHF, may derive a significant benefit. The only clinical trial to show a reduction in non-fatal coronary events used a higher n-3 fatty acid dose than used in the other studies, which raises the question of whether more is better for certain clinical outcomes. That trial however, was an open-label study, and used much lower doses of statin than used in the other trials. Therefore, no firm conclusions can be drawn about the role of n-3 fatty acids until further research can resolve these questions.

Original languageEnglish (US)
Title of host publicationThe Omega-3 Fatty Acid Deficiency Syndrome
Subtitle of host publicationOpportunities for Disease Prevention
PublisherNova Science Publishers, Inc.
Pages213-232
Number of pages20
ISBN (Print)9781624177033
StatePublished - Mar 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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    Barringer, T. A., & Harris, W. S. (2013). Omega-3 fatty acid deficiency and cardiovascular disease. In The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention (pp. 213-232). Nova Science Publishers, Inc..