Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology

Minh Vu Chuong Nguyen, Christy A. Felice, Fang Du, Matthew V. Covey, John K. Robinson, Gail Mandel, Nurit Ballas

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Mutations in the methyl-CpG binding protein 2 gene, Mecp2, affect primarily the brain and lead to a wide range of neuropsychiatric disorders, most commonly Rett syndrome (RTT). Although the neuropathology of RTT is well understood, the cellular and molecular mechanism(s), which lead to the disease initiation and progression, has yet to be elucidated. RTT was initially attributed only to neuronal dysfunction, but our recent studies and those of others show that RTT is not exclusively neuronal but rather also involves interactions between neurons and glia. Importantly, studies have shown that MeCP2-restored astrocytes and microglia are able to attenuate the disease progression in otherwise MeCP2-null mice. Here we show that another type of glia, oligodendrocytes, and their progenitors are also involved in manifestation of specific RTT symptoms. Mice that lost MeCP2 specifically in the oligodendrocyte lineage cells, although overall normal, were more active and developed severe hindlimb clasping phenotypes. Inversely, restoration of MeCP2 in oligodendrocyte lineage cells, in otherwise MeCP2-null mice, although only mildly prolonging their lifespan, significantly improved the locomotor deficits and hindlimb clasping phenotype, both in male and female mice, and fully restored the body weight in male mice. Finally, we found that the level of some myelin-related proteins was impaired in the MeCP2-null mice. Expression of MeCP2 in oligodendrocytes of these mice only partially restored their expression, suggesting that there is a non-cell-autonomous effect by other cell types in the brains on the expression of myelin-related proteins in oligodendrocytes.

Original languageEnglish (US)
Pages (from-to)18764-18774
Number of pages11
JournalJournal of Neuroscience
Volume33
Issue number48
DOIs
StatePublished - 2013

Fingerprint

Rett Syndrome
Oligodendroglia
Myelin Proteins
Hindlimb
Neuroglia
Disease Progression
Methyl-CpG-Binding Protein 2
Phenotype
Brain
Microglia
Neuropathology
Astrocytes
Body Weight
Neurons
Mutation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Nguyen, M. V. C., Felice, C. A., Du, F., Covey, M. V., Robinson, J. K., Mandel, G., & Ballas, N. (2013). Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology. Journal of Neuroscience, 33(48), 18764-18774. https://doi.org/10.1523/JNEUROSCI.2657-13.2013

Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology. / Nguyen, Minh Vu Chuong; Felice, Christy A.; Du, Fang; Covey, Matthew V.; Robinson, John K.; Mandel, Gail; Ballas, Nurit.

In: Journal of Neuroscience, Vol. 33, No. 48, 2013, p. 18764-18774.

Research output: Contribution to journalArticle

Nguyen, MVC, Felice, CA, Du, F, Covey, MV, Robinson, JK, Mandel, G & Ballas, N 2013, 'Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology', Journal of Neuroscience, vol. 33, no. 48, pp. 18764-18774. https://doi.org/10.1523/JNEUROSCI.2657-13.2013
Nguyen, Minh Vu Chuong ; Felice, Christy A. ; Du, Fang ; Covey, Matthew V. ; Robinson, John K. ; Mandel, Gail ; Ballas, Nurit. / Oligodendrocyte lineage cells contribute unique features to rett syndrome neuropathology. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 48. pp. 18764-18774.
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