Olfactory dysfunction in familial parkinsonism

K. Markopoulou, K. W. Larsen, E. K. Wszolek, M. A. Denson, A. E. Lang, Ronald Pfeiffer, Z. K. Wszolek

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Impaired olfactory function is commonly observed in idiopathic Parkinson's disease (IPD). However, it is unknown whether it is also found in familial parkinsonism. To address this issue we administered a smell test to 12 affected, three monosymptomatic, and 12 at-risk individuals from six large parkinsonian kindreds. Three kindreds exhibited an IPD phenotype and three exhibited a parkinsonism-plus syndrome (PPS) phenotype. All but one of the affected individuals had impaired olfactory function. In contrast, only five of the 12 at-risk individuals had impaired olfactory function. The degree of olfactory impairment in the at-risk individuals was less severe than in the affected individuals. The difference in the degree of olfactory impairment in individuals exhibiting the IPD and the PPS phenotypes was not statistically significant. These findings suggest that olfactory dysfunction is a phenotypic characteristic of familial parkinsonism and that it is independent of the kindred phenotype. The appearance of olfactory dysfunction soon after disease onset raises the possibility that it is part of the neurodegenerative disease process.

Original languageEnglish (US)
Pages (from-to)1262-1267
Number of pages6
JournalNeurology
Volume49
Issue number5
StatePublished - Nov 1997
Externally publishedYes

Fingerprint

Parkinsonian Disorders
Parkinson Disease
Phenotype
Smell
Neurodegenerative Diseases

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Markopoulou, K., Larsen, K. W., Wszolek, E. K., Denson, M. A., Lang, A. E., Pfeiffer, R., & Wszolek, Z. K. (1997). Olfactory dysfunction in familial parkinsonism. Neurology, 49(5), 1262-1267.

Olfactory dysfunction in familial parkinsonism. / Markopoulou, K.; Larsen, K. W.; Wszolek, E. K.; Denson, M. A.; Lang, A. E.; Pfeiffer, Ronald; Wszolek, Z. K.

In: Neurology, Vol. 49, No. 5, 11.1997, p. 1262-1267.

Research output: Contribution to journalArticle

Markopoulou, K, Larsen, KW, Wszolek, EK, Denson, MA, Lang, AE, Pfeiffer, R & Wszolek, ZK 1997, 'Olfactory dysfunction in familial parkinsonism', Neurology, vol. 49, no. 5, pp. 1262-1267.
Markopoulou K, Larsen KW, Wszolek EK, Denson MA, Lang AE, Pfeiffer R et al. Olfactory dysfunction in familial parkinsonism. Neurology. 1997 Nov;49(5):1262-1267.
Markopoulou, K. ; Larsen, K. W. ; Wszolek, E. K. ; Denson, M. A. ; Lang, A. E. ; Pfeiffer, Ronald ; Wszolek, Z. K. / Olfactory dysfunction in familial parkinsonism. In: Neurology. 1997 ; Vol. 49, No. 5. pp. 1262-1267.
@article{7bac19cbab0d4c00833d619053e91f1e,
title = "Olfactory dysfunction in familial parkinsonism",
abstract = "Impaired olfactory function is commonly observed in idiopathic Parkinson's disease (IPD). However, it is unknown whether it is also found in familial parkinsonism. To address this issue we administered a smell test to 12 affected, three monosymptomatic, and 12 at-risk individuals from six large parkinsonian kindreds. Three kindreds exhibited an IPD phenotype and three exhibited a parkinsonism-plus syndrome (PPS) phenotype. All but one of the affected individuals had impaired olfactory function. In contrast, only five of the 12 at-risk individuals had impaired olfactory function. The degree of olfactory impairment in the at-risk individuals was less severe than in the affected individuals. The difference in the degree of olfactory impairment in individuals exhibiting the IPD and the PPS phenotypes was not statistically significant. These findings suggest that olfactory dysfunction is a phenotypic characteristic of familial parkinsonism and that it is independent of the kindred phenotype. The appearance of olfactory dysfunction soon after disease onset raises the possibility that it is part of the neurodegenerative disease process.",
author = "K. Markopoulou and Larsen, {K. W.} and Wszolek, {E. K.} and Denson, {M. A.} and Lang, {A. E.} and Ronald Pfeiffer and Wszolek, {Z. K.}",
year = "1997",
month = "11",
language = "English (US)",
volume = "49",
pages = "1262--1267",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Olfactory dysfunction in familial parkinsonism

AU - Markopoulou, K.

AU - Larsen, K. W.

AU - Wszolek, E. K.

AU - Denson, M. A.

AU - Lang, A. E.

AU - Pfeiffer, Ronald

AU - Wszolek, Z. K.

PY - 1997/11

Y1 - 1997/11

N2 - Impaired olfactory function is commonly observed in idiopathic Parkinson's disease (IPD). However, it is unknown whether it is also found in familial parkinsonism. To address this issue we administered a smell test to 12 affected, three monosymptomatic, and 12 at-risk individuals from six large parkinsonian kindreds. Three kindreds exhibited an IPD phenotype and three exhibited a parkinsonism-plus syndrome (PPS) phenotype. All but one of the affected individuals had impaired olfactory function. In contrast, only five of the 12 at-risk individuals had impaired olfactory function. The degree of olfactory impairment in the at-risk individuals was less severe than in the affected individuals. The difference in the degree of olfactory impairment in individuals exhibiting the IPD and the PPS phenotypes was not statistically significant. These findings suggest that olfactory dysfunction is a phenotypic characteristic of familial parkinsonism and that it is independent of the kindred phenotype. The appearance of olfactory dysfunction soon after disease onset raises the possibility that it is part of the neurodegenerative disease process.

AB - Impaired olfactory function is commonly observed in idiopathic Parkinson's disease (IPD). However, it is unknown whether it is also found in familial parkinsonism. To address this issue we administered a smell test to 12 affected, three monosymptomatic, and 12 at-risk individuals from six large parkinsonian kindreds. Three kindreds exhibited an IPD phenotype and three exhibited a parkinsonism-plus syndrome (PPS) phenotype. All but one of the affected individuals had impaired olfactory function. In contrast, only five of the 12 at-risk individuals had impaired olfactory function. The degree of olfactory impairment in the at-risk individuals was less severe than in the affected individuals. The difference in the degree of olfactory impairment in individuals exhibiting the IPD and the PPS phenotypes was not statistically significant. These findings suggest that olfactory dysfunction is a phenotypic characteristic of familial parkinsonism and that it is independent of the kindred phenotype. The appearance of olfactory dysfunction soon after disease onset raises the possibility that it is part of the neurodegenerative disease process.

UR - http://www.scopus.com/inward/record.url?scp=0030698691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030698691&partnerID=8YFLogxK

M3 - Article

C2 - 9371905

AN - SCOPUS:0030698691

VL - 49

SP - 1262

EP - 1267

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 5

ER -