TY - JOUR
T1 - OKT3 prophylaxis in renal grafts with prolonged cold ischemia times
T2 - Association with improvement in long-term survival
AU - Abramowicz, Daniel
AU - Norman, Douglas J.
AU - Vereerstraeten, Pierre
AU - Goldman, Michel
AU - De Pauw, Luc
AU - Vanherweghem, Jean Louis
AU - Kinnaert, Paul
AU - Kahana, Lawrence
AU - Stuart, Frank P.
AU - Thistlethwaite, James R.
AU - Shield, Charles F.
AU - Monaco, Anthony
AU - Wu, Shu Chen
AU - Haverty, Thomas P.
PY - 1996
Y1 - 1996
N2 - The data on patients participating in two randomized, prospective studies with similar immunosuppressive regimens were updated and combined to evaluate the long-term effects of OKT3 according to cold ischemia lime (≤ or > 24 hr). Among 159 patients in the OKT3 and 153 in the cyclosporine A (CsA) group, 8 and 12 deaths occurred, respectively (P = NS). In patients with cold ischemia > 24 hours, OKT3 prophylaxis resulted in a lower mean number of rejection episodes per patient than did CsA prophylaxis within one year (mean ± SEM: 0.87 ± 0.11 vs. 1.35 ± 0.14, respectively; P = 0.008) and within five years (1.07 ± 0.12 vs. 1.49 ± 0.15, respectively; P = 0.032). In contrast, rejection incidences in patients with cold ischemia ≤ 24 hours was not significantly different in the two groups. In all study patients, there was a trend towards higher graft survival rates in the OKT3 group versus the CsA group (at 5 years, 73% vs. 66%, respectively; P = 0.182). Among recipients of kidneys with cold ischemia times > 24 hours, OKT3 patients had significantly higher graft survival than CsA patients at two years (84% vs. 64%, respectively) and at five years (71% vs. 56%, respectively; P = 0.045). Significant differences were not observed in recipients of kidneys with cold ischemia times ≤ 24 hours. In conclusion, patients receiving renal grafts with long cold ischemia times strongly benefit from OKT3 prophylaxis.
AB - The data on patients participating in two randomized, prospective studies with similar immunosuppressive regimens were updated and combined to evaluate the long-term effects of OKT3 according to cold ischemia lime (≤ or > 24 hr). Among 159 patients in the OKT3 and 153 in the cyclosporine A (CsA) group, 8 and 12 deaths occurred, respectively (P = NS). In patients with cold ischemia > 24 hours, OKT3 prophylaxis resulted in a lower mean number of rejection episodes per patient than did CsA prophylaxis within one year (mean ± SEM: 0.87 ± 0.11 vs. 1.35 ± 0.14, respectively; P = 0.008) and within five years (1.07 ± 0.12 vs. 1.49 ± 0.15, respectively; P = 0.032). In contrast, rejection incidences in patients with cold ischemia ≤ 24 hours was not significantly different in the two groups. In all study patients, there was a trend towards higher graft survival rates in the OKT3 group versus the CsA group (at 5 years, 73% vs. 66%, respectively; P = 0.182). Among recipients of kidneys with cold ischemia times > 24 hours, OKT3 patients had significantly higher graft survival than CsA patients at two years (84% vs. 64%, respectively) and at five years (71% vs. 56%, respectively; P = 0.045). Significant differences were not observed in recipients of kidneys with cold ischemia times ≤ 24 hours. In conclusion, patients receiving renal grafts with long cold ischemia times strongly benefit from OKT3 prophylaxis.
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U2 - 10.1038/ki.1996.106
DO - 10.1038/ki.1996.106
M3 - Article
C2 - 8648918
AN - SCOPUS:9044225150
SN - 0085-2538
VL - 49
SP - 768
EP - 772
JO - Kidney International
JF - Kidney International
IS - 3
ER -