Official American thoracic society/Infectious diseases society of America/Centers for disease control and prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children

David Lewinsohn, Michael K. Leonard, Philip A. Lobue, David L. Cohn, Charles L. Daley, Ed Desmond, Joseph Keane, Deborah Lewinsohn, Ann M. Loeffler, Gerald H. Mazurek, Richard J. O'Brien, Madhukar Pai, Luca Richeldi, Max Salfinger, Thomas M. Shinnick, Timothy R. Sterling, David M. Warshauer, Gail L. Woods

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of disease (latent tuberculosis infection [LTBI]). Tuberculosis disease is a leading cause of infectious disease morbidity and mortality worldwide, yet many questions related to its diagnosis remain. Methods. A task force supported by the American Thoracic Society, Centers for Disease Control and Prevention, and Infectious Diseases Society of America searched, selected, and synthesized relevant evidence. The evidence was then used as the basis for recommendations about the diagnosis of tuberculosis disease and LTBI in adults and children. The recommendations were formulated, written, and graded using the Grading, Recommendations, Assessment, Development and Evaluation (GRADE) approach. Results. Twenty-three evidence-based recommendations about diagnostic testing for latent tuberculosis infection, pulmonary tuberculosis, and extrapulmonary tuberculosis are provided. Six of the recommendations are strong, whereas the remaining 17 are conditional. Conclusions. These guidelines are not intended to impose a standard of care. They provide the basis for rational decisions in the diagnosis of tuberculosis in the context of the existing evidence. No guidelines can take into account all of the often compelling unique individual clinical circumstances.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalClinical Infectious Diseases
Volume64
Issue number2
DOIs
StatePublished - 2017

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Centers for Disease Control and Prevention (U.S.)
Practice Guidelines
Communicable Diseases
Tuberculosis
Latent Tuberculosis
Thorax
Guidelines
Advisory Committees
Standard of Care
Pulmonary Tuberculosis
Mycobacterium tuberculosis
Signs and Symptoms
Morbidity
Mortality

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Official American thoracic society/Infectious diseases society of America/Centers for disease control and prevention clinical practice guidelines : diagnosis of tuberculosis in adults and children. / Lewinsohn, David; Leonard, Michael K.; Lobue, Philip A.; Cohn, David L.; Daley, Charles L.; Desmond, Ed; Keane, Joseph; Lewinsohn, Deborah; Loeffler, Ann M.; Mazurek, Gerald H.; O'Brien, Richard J.; Pai, Madhukar; Richeldi, Luca; Salfinger, Max; Shinnick, Thomas M.; Sterling, Timothy R.; Warshauer, David M.; Woods, Gail L.

In: Clinical Infectious Diseases, Vol. 64, No. 2, 2017, p. 111-115.

Research output: Contribution to journalArticle

Lewinsohn, D, Leonard, MK, Lobue, PA, Cohn, DL, Daley, CL, Desmond, E, Keane, J, Lewinsohn, D, Loeffler, AM, Mazurek, GH, O'Brien, RJ, Pai, M, Richeldi, L, Salfinger, M, Shinnick, TM, Sterling, TR, Warshauer, DM & Woods, GL 2017, 'Official American thoracic society/Infectious diseases society of America/Centers for disease control and prevention clinical practice guidelines: diagnosis of tuberculosis in adults and children', Clinical Infectious Diseases, vol. 64, no. 2, pp. 111-115. https://doi.org/10.1093/cid/ciw778
Lewinsohn, David ; Leonard, Michael K. ; Lobue, Philip A. ; Cohn, David L. ; Daley, Charles L. ; Desmond, Ed ; Keane, Joseph ; Lewinsohn, Deborah ; Loeffler, Ann M. ; Mazurek, Gerald H. ; O'Brien, Richard J. ; Pai, Madhukar ; Richeldi, Luca ; Salfinger, Max ; Shinnick, Thomas M. ; Sterling, Timothy R. ; Warshauer, David M. ; Woods, Gail L. / Official American thoracic society/Infectious diseases society of America/Centers for disease control and prevention clinical practice guidelines : diagnosis of tuberculosis in adults and children. In: Clinical Infectious Diseases. 2017 ; Vol. 64, No. 2. pp. 111-115.
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