Office-based dynamic imaging of vocal cords in awake patients with swept-source optical coherence tomography

Lingfeng Yu, Gangjun Liu, Marc Rubinstein, Arya Saidi, Brian J.F. Wong, Zhongping Chen

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient index (GRIN) lens-based probe capable of capturing images of the human larynx by use of swept-source OCT during a typical office-based laryngoscopy examination is presented. In vivo OCT imaging of the human larynx is demonstrated with a rate of 40 frames per second. Dynamic vibration of the vocal folds is recorded to provide not only high-resolution cross-sectional tissue structures but also vibration parameters, such as the vibration frequency and magnitude of the vocal cords, which provides important information for clinical diagnosis and treatment, as well as fundamental research of the voice itself. Office-based OCT is a promising imaging modality to study the larynx for physicians in otolaryngology.

Original languageEnglish (US)
Article number064020
JournalJournal of biomedical optics
Issue number6
StatePublished - 2009
Externally publishedYes


  • Biomedical imaging
  • Early diagnosis
  • Laryngeal cancer
  • Larynx
  • Optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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