OFF-off rebound dyskinesia in subthalamic nucleus deep brain stimulation of parkinson's disease

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A 61-year-old man with Parkinson's disease (PD), motor fluctuations, and dyskinesias underwent bilateral implantation of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN). One month after surgery, DBS was optimized to bilateral monopolar settings at the most proximal electrode just superior to the STN, which improved motor fluctuations and dyskinesias. At several postoperative evaluations off medications overnight, both stimulators were turned off and within 60 seconds he developed severe dyskinesias. When the stimulators were turned back on, the dyskinesias soon resolved. This article is a first report of a unique pattern of rebound-type dyskinesia that occurred in the off medication state produced by stopping STN DBS.

Original languageEnglish (US)
Pages (from-to)1487-1490
Number of pages4
JournalMovement Disorders
Volume21
Issue number9
DOIs
StatePublished - Sep 2006
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Dyskinesias
Parkinson Disease
Electrodes

Keywords

  • Deep brain stimulation
  • Dyskinesia
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

@article{b170656309994898b305b6b4c717f9f2,
title = "OFF-off rebound dyskinesia in subthalamic nucleus deep brain stimulation of parkinson's disease",
abstract = "A 61-year-old man with Parkinson's disease (PD), motor fluctuations, and dyskinesias underwent bilateral implantation of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN). One month after surgery, DBS was optimized to bilateral monopolar settings at the most proximal electrode just superior to the STN, which improved motor fluctuations and dyskinesias. At several postoperative evaluations off medications overnight, both stimulators were turned off and within 60 seconds he developed severe dyskinesias. When the stimulators were turned back on, the dyskinesias soon resolved. This article is a first report of a unique pattern of rebound-type dyskinesia that occurred in the off medication state produced by stopping STN DBS.",
keywords = "Deep brain stimulation, Dyskinesia, Parkinson's disease",
author = "Matthew Brodsky and Hogarth, {Penelope (Penny)} and John Nutt",
year = "2006",
month = "9",
doi = "10.1002/mds.20964",
language = "English (US)",
volume = "21",
pages = "1487--1490",
journal = "Movement Disorders",
issn = "0885-3185",
publisher = "John Wiley and Sons Inc.",
number = "9",

}

TY - JOUR

T1 - OFF-off rebound dyskinesia in subthalamic nucleus deep brain stimulation of parkinson's disease

AU - Brodsky, Matthew

AU - Hogarth, Penelope (Penny)

AU - Nutt, John

PY - 2006/9

Y1 - 2006/9

N2 - A 61-year-old man with Parkinson's disease (PD), motor fluctuations, and dyskinesias underwent bilateral implantation of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN). One month after surgery, DBS was optimized to bilateral monopolar settings at the most proximal electrode just superior to the STN, which improved motor fluctuations and dyskinesias. At several postoperative evaluations off medications overnight, both stimulators were turned off and within 60 seconds he developed severe dyskinesias. When the stimulators were turned back on, the dyskinesias soon resolved. This article is a first report of a unique pattern of rebound-type dyskinesia that occurred in the off medication state produced by stopping STN DBS.

AB - A 61-year-old man with Parkinson's disease (PD), motor fluctuations, and dyskinesias underwent bilateral implantation of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN). One month after surgery, DBS was optimized to bilateral monopolar settings at the most proximal electrode just superior to the STN, which improved motor fluctuations and dyskinesias. At several postoperative evaluations off medications overnight, both stimulators were turned off and within 60 seconds he developed severe dyskinesias. When the stimulators were turned back on, the dyskinesias soon resolved. This article is a first report of a unique pattern of rebound-type dyskinesia that occurred in the off medication state produced by stopping STN DBS.

KW - Deep brain stimulation

KW - Dyskinesia

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=33750306863&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750306863&partnerID=8YFLogxK

U2 - 10.1002/mds.20964

DO - 10.1002/mds.20964

M3 - Article

C2 - 16721730

AN - SCOPUS:33750306863

VL - 21

SP - 1487

EP - 1490

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 9

ER -