Of spiders and crabs: The emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer

Mandi Murph, Tamotsu Tanaka, Shuying Liu, Gordon B. Mills

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two small lysophospholipids, are potent inducers of many of the hallmarks of cancer including cell proliferation, survival, migration, invasion, and neovascularization in in vitro and in vivo tumor models. Furthermore, the enzymes metabolizing LPA and S1P and their receptors are aberrant in multiple cancer lineages and exhibit transforming activity altering patterns and targets for metastasis. Several recent studies show the remarkable activity of new chemical genomics and/or potential novel drugs in preclinical models. Combined with the physiologic and pathophysiologic activities of LPA and S1P, these studies suggest the implementation of preclinical and clinical evaluation of LPA and S1P as therapeutic targets.

Original languageEnglish (US)
Pages (from-to)6598-6602
Number of pages5
JournalClinical Cancer Research
Volume12
Issue number22
DOIs
StatePublished - Nov 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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