TY - JOUR
T1 - Of spiders and crabs
T2 - The emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer
AU - Murph, Mandi
AU - Tanaka, Tamotsu
AU - Liu, Shuying
AU - Mills, Gordon B.
PY - 2006/11/15
Y1 - 2006/11/15
N2 - Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two small lysophospholipids, are potent inducers of many of the hallmarks of cancer including cell proliferation, survival, migration, invasion, and neovascularization in in vitro and in vivo tumor models. Furthermore, the enzymes metabolizing LPA and S1P and their receptors are aberrant in multiple cancer lineages and exhibit transforming activity altering patterns and targets for metastasis. Several recent studies show the remarkable activity of new chemical genomics and/or potential novel drugs in preclinical models. Combined with the physiologic and pathophysiologic activities of LPA and S1P, these studies suggest the implementation of preclinical and clinical evaluation of LPA and S1P as therapeutic targets.
AB - Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two small lysophospholipids, are potent inducers of many of the hallmarks of cancer including cell proliferation, survival, migration, invasion, and neovascularization in in vitro and in vivo tumor models. Furthermore, the enzymes metabolizing LPA and S1P and their receptors are aberrant in multiple cancer lineages and exhibit transforming activity altering patterns and targets for metastasis. Several recent studies show the remarkable activity of new chemical genomics and/or potential novel drugs in preclinical models. Combined with the physiologic and pathophysiologic activities of LPA and S1P, these studies suggest the implementation of preclinical and clinical evaluation of LPA and S1P as therapeutic targets.
UR - http://www.scopus.com/inward/record.url?scp=33845343972&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33845343972&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-06-1721
DO - 10.1158/1078-0432.CCR-06-1721
M3 - Article
C2 - 17121877
AN - SCOPUS:33845343972
VL - 12
SP - 6598
EP - 6602
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 22
ER -