TY - JOUR
T1 - Of rafts and moving water.
AU - Cohen, David M.
PY - 2003
Y1 - 2003
N2 - The ability to respond rapidly to changes in tonicity is crucial for cellular and organismal survival. Sensors of osmotic stress are beginning to be discovered. For example, results from expression cloning in a heterologous system have implicated GAP43 as a component of a peripheral nervous system sensor of hypotonicity. These results and the role of lipid rafts, protein kinase C, and members of the phospholipase C-delta family are discussed in the context of cellular responses to osmotic stress. Calcium is also involved in the osmotic stress response, and both intracellular calcium released through inositol trisphosphate receptors and extracellular calcium transported through TRPV4 (a member of the transient receptor potential family) may contribute.
AB - The ability to respond rapidly to changes in tonicity is crucial for cellular and organismal survival. Sensors of osmotic stress are beginning to be discovered. For example, results from expression cloning in a heterologous system have implicated GAP43 as a component of a peripheral nervous system sensor of hypotonicity. These results and the role of lipid rafts, protein kinase C, and members of the phospholipase C-delta family are discussed in the context of cellular responses to osmotic stress. Calcium is also involved in the osmotic stress response, and both intracellular calcium released through inositol trisphosphate receptors and extracellular calcium transported through TRPV4 (a member of the transient receptor potential family) may contribute.
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U2 - 10.1126/stke.2003.199.pe36
DO - 10.1126/stke.2003.199.pe36
M3 - Review article
C2 - 12966185
AN - SCOPUS:18744436010
SN - 1937-9145
VL - 2003
SP - pe36
JO - Science's STKE : signal transduction knowledge environment
JF - Science's STKE : signal transduction knowledge environment
IS - 199
ER -