Ocular toxicity of antineoplastic agents

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil), retinopathy (mitotane, tamoxifen), corneal opacities (tamoxifen), cataracts (busulfan, methotrexate), and optic or ocular motor abnormalities (carmustine, vinblastine, vincristine). Based on the data in the National Registry of Drug-Induced Ocular Side Effects and the literature, adverse ocular reactions of the more commonly used chemotherapeutic agents are reviewed.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalOphthalmology
Volume90
Issue number1
StatePublished - 1983

Fingerprint

Antineoplastic Agents
Tamoxifen
Methotrexate
Fluorouracil
Mitotane
Eye Abnormalities
Lacrimal Apparatus Diseases
Corneal Opacity
Carmustine
Busulfan
Vinblastine
Vincristine
Pharmaceutical Preparations
Cataract
Registries
Fibrosis
Survival

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular toxicity of antineoplastic agents. / Fraunfelder, Frederick (Fritz); Meyer, S. M.

In: Ophthalmology, Vol. 90, No. 1, 1983, p. 1-3.

Research output: Contribution to journalArticle

Fraunfelder, FF & Meyer, SM 1983, 'Ocular toxicity of antineoplastic agents', Ophthalmology, vol. 90, no. 1, pp. 1-3.
Fraunfelder, Frederick (Fritz) ; Meyer, S. M. / Ocular toxicity of antineoplastic agents. In: Ophthalmology. 1983 ; Vol. 90, No. 1. pp. 1-3.
@article{d96f44a710054bebaa38bfb471f32cc1,
title = "Ocular toxicity of antineoplastic agents",
abstract = "The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil), retinopathy (mitotane, tamoxifen), corneal opacities (tamoxifen), cataracts (busulfan, methotrexate), and optic or ocular motor abnormalities (carmustine, vinblastine, vincristine). Based on the data in the National Registry of Drug-Induced Ocular Side Effects and the literature, adverse ocular reactions of the more commonly used chemotherapeutic agents are reviewed.",
author = "Fraunfelder, {Frederick (Fritz)} and Meyer, {S. M.}",
year = "1983",
language = "English (US)",
volume = "90",
pages = "1--3",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Ocular toxicity of antineoplastic agents

AU - Fraunfelder, Frederick (Fritz)

AU - Meyer, S. M.

PY - 1983

Y1 - 1983

N2 - The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil), retinopathy (mitotane, tamoxifen), corneal opacities (tamoxifen), cataracts (busulfan, methotrexate), and optic or ocular motor abnormalities (carmustine, vinblastine, vincristine). Based on the data in the National Registry of Drug-Induced Ocular Side Effects and the literature, adverse ocular reactions of the more commonly used chemotherapeutic agents are reviewed.

AB - The increased use of chemotherapeutic agents has resulted in longer patient survival; consequently, the ophthalmologist is seeing more patients with adverse ocular side effects secondary to these antineoplastic agents. Many of these drugs cause aggravating ocular irritation (fluorouracil, methotrexate), canalicular fibrosis with epiphora (fluorouracil), retinopathy (mitotane, tamoxifen), corneal opacities (tamoxifen), cataracts (busulfan, methotrexate), and optic or ocular motor abnormalities (carmustine, vinblastine, vincristine). Based on the data in the National Registry of Drug-Induced Ocular Side Effects and the literature, adverse ocular reactions of the more commonly used chemotherapeutic agents are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=0020693243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020693243&partnerID=8YFLogxK

M3 - Article

C2 - 6828303

AN - SCOPUS:0020693243

VL - 90

SP - 1

EP - 3

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 1

ER -