Ocular side effects possibly associated with isotretinoin usage

Frederick (Fritz) Fraunfelder, F. W. Fraunfelder, Ralph Edwards

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

PURPOSE: To evaluate reported ocular side effects associated with isotretinoin usage. METHODS: One thousand seven hundred forty-one case reports received from spontaneous reporting systems, data from the Drug Safety Section of Roche Pharmaceuticals, and the world's literature were evaluated using the World Health Organization Causality Assessment Guide of Suspected Adverse Reactions. RESULTS: Thirty-eight different signs or symptoms of ocular abnormalities associated with isotretinoin usage have been classified as 'certain,' 'probable/likely,' 'possible,' 'unlikely,' or 'conditional/unclassifiable.' CONCLUSION: Adverse ocular side effects secondary to isotretinoin that are 'certain' include abnormal meibomian gland secretion, blepharoconjunctivitis, corneal opacities, decreased dark adaptation, decreased tolerance to contact lens, decreased vision, increased tear osmolarity, keratitis, meibomian gland atrophy, myopia, ocular discomfort, ocular sicca, photophobia, and teratogenic ocular abnormalities. Those that are 'probable/likely' are decreased color vision (reversible) and permanent loss of dark adaptation. Those that have a 'possible' association include permanent keratoconjunctivitis sicca. Suggested guidelines for ocular examination for patients on isotretinoin are given.

Original languageEnglish (US)
Pages (from-to)299-305
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume132
Issue number3
DOIs
StatePublished - 2001

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Isotretinoin
Meibomian Glands
Eye Abnormalities
Dark Adaptation
Keratoconjunctivitis Sicca
Corneal Opacity
Photophobia
Color Vision
Keratitis
Contact Lenses
Myopia
Tears
Information Systems
Causality
Pharmaceutical Preparations
Osmolar Concentration
Signs and Symptoms
Atrophy
Research Design
Guidelines

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Ocular side effects possibly associated with isotretinoin usage. / Fraunfelder, Frederick (Fritz); Fraunfelder, F. W.; Edwards, Ralph.

In: American Journal of Ophthalmology, Vol. 132, No. 3, 2001, p. 299-305.

Research output: Contribution to journalArticle

Fraunfelder, Frederick (Fritz) ; Fraunfelder, F. W. ; Edwards, Ralph. / Ocular side effects possibly associated with isotretinoin usage. In: American Journal of Ophthalmology. 2001 ; Vol. 132, No. 3. pp. 299-305.
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