Abstract
Purpose of review Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are numerous and can often involve the eye. This review highlights the ocular complications associated with IBD including the critical role the ophthalmologist can play in the diagnosis of IBD, the pathogenesis of IBD, its ocular complications, and the treatment of ocular inflammation associated with IBD. Recent findings Polygenic and environmental influences, as well as gut microbial dysbiosis, have been implicated in the pathogenesis of IBD. IBD and its EIMs appear to respond well to TNFa-Targeted biologics. Summary IBD is thought to be caused by polygenic and environmental influences, including a dysbiotic gut microbiota. It is a systemic immune-mediated disease with varying types of ocular manifestations that can precede, occur simultaneously, or follow intestinal involvement. The diagnosis of IBD can be confused with other seronegative spondyloarthropathies as well as Behçet's disease. Treatment of IBD-Associated ocular inflammation can range from corticosteroids to steroid-sparing immunosuppression such as azathioprine or methotrexate. Refractory disease can respond well to TNFa inhibitors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 552-560 |
| Number of pages | 9 |
| Journal | Current Opinion in Ophthalmology |
| Volume | 27 |
| Issue number | 6 |
| DOIs | |
| State | Published - Nov 1 2016 |
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Keywords
- Gut Microbiome
- Inflammatory Bowel Disease
- Ocular Inflammation
ASJC Scopus subject areas
- Ophthalmology
Cite this
Ocular manifestations of inflammatory bowel disease. / Thomas, Akshay S.; Lin, Phoebe.
In: Current Opinion in Ophthalmology, Vol. 27, No. 6, 01.11.2016, p. 552-560.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Ocular manifestations of inflammatory bowel disease
AU - Thomas, Akshay S.
AU - Lin, Phoebe
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Purpose of review Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are numerous and can often involve the eye. This review highlights the ocular complications associated with IBD including the critical role the ophthalmologist can play in the diagnosis of IBD, the pathogenesis of IBD, its ocular complications, and the treatment of ocular inflammation associated with IBD. Recent findings Polygenic and environmental influences, as well as gut microbial dysbiosis, have been implicated in the pathogenesis of IBD. IBD and its EIMs appear to respond well to TNFa-Targeted biologics. Summary IBD is thought to be caused by polygenic and environmental influences, including a dysbiotic gut microbiota. It is a systemic immune-mediated disease with varying types of ocular manifestations that can precede, occur simultaneously, or follow intestinal involvement. The diagnosis of IBD can be confused with other seronegative spondyloarthropathies as well as Behçet's disease. Treatment of IBD-Associated ocular inflammation can range from corticosteroids to steroid-sparing immunosuppression such as azathioprine or methotrexate. Refractory disease can respond well to TNFa inhibitors.
AB - Purpose of review Extraintestinal manifestations (EIMs) of inflammatory bowel disease (IBD) are numerous and can often involve the eye. This review highlights the ocular complications associated with IBD including the critical role the ophthalmologist can play in the diagnosis of IBD, the pathogenesis of IBD, its ocular complications, and the treatment of ocular inflammation associated with IBD. Recent findings Polygenic and environmental influences, as well as gut microbial dysbiosis, have been implicated in the pathogenesis of IBD. IBD and its EIMs appear to respond well to TNFa-Targeted biologics. Summary IBD is thought to be caused by polygenic and environmental influences, including a dysbiotic gut microbiota. It is a systemic immune-mediated disease with varying types of ocular manifestations that can precede, occur simultaneously, or follow intestinal involvement. The diagnosis of IBD can be confused with other seronegative spondyloarthropathies as well as Behçet's disease. Treatment of IBD-Associated ocular inflammation can range from corticosteroids to steroid-sparing immunosuppression such as azathioprine or methotrexate. Refractory disease can respond well to TNFa inhibitors.
KW - Gut Microbiome
KW - Inflammatory Bowel Disease
KW - Ocular Inflammation
UR - http://www.scopus.com/inward/record.url?scp=84984680159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84984680159&partnerID=8YFLogxK
U2 - 10.1097/ICU.0000000000000310
DO - 10.1097/ICU.0000000000000310
M3 - Review article
C2 - 27585211
AN - SCOPUS:84984680159
VL - 27
SP - 552
EP - 560
JO - Current Opinion in Ophthalmology
JF - Current Opinion in Ophthalmology
SN - 1040-8738
IS - 6
ER -