Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in osteoporotic fractures in men (MrOS) sleep study

Akram Khan, Stephanie L. Harrison, Eric J. Kezirian, Sonia Ancoli-Israel, Daniel O'Hearn, Eric Orwoll, Susan Redline, Kristine Ensrud, Katie L. Stone

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Study Objectives: Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and qualityof life in a community-based cohort of men ≥ 65 years-old. Design, Intervention and Measurements: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) <15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (<5 [referent group], 5 to <15, 15 to <30, and ≥ 30). Daytime somnolence, sleep-related quality of life, sleep disturbance, general quality of life, depressive symptoms, and health status were quantified using Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), Geriatric Depression Scale-15 (GDS), and self-perceived health status, respectively. Results: Prevalence of REM-predominant OSA (AHI-REM ≥ 5) was 42.8% if OSA was defined as AHI ≥ 15 and 14.4% if OSA was defined as AHI ≥ 5. Higher AHI-REM was associated with polysomnographic indices of poorer sleep architecture (reduced total sleep time, sleep effi ciency, REM sleep duration and proportion). Adjusting for age, BMI, and study site, higher AHI-REM was not associated with subjective sleep measures (ESS, FOSQ, PSQI), lower quality of life (SF-12), or greater depressive symptoms (GDS). Conclusions: In a community-based sample of older adult men ≥ 65 years-old, REM-predominant OSA was highly prevalent and was associated with objective indices of poorer sleep quality on polysomnography but not with subjective measures of daytime sleepiness or quality of life.

Original languageEnglish (US)
JournalJournal of Clinical Sleep Medicine
Volume9
Issue number3
DOIs
StatePublished - 2013

Fingerprint

Osteoporotic Fractures
REM Sleep
Obstructive Sleep Apnea
Sleep
Quality of Life
Apnea
Depression
Health Status
Polysomnography
Geriatrics
Cross-Sectional Studies

Keywords

  • Disorders of excessive somnolence
  • Epidemiology
  • Obstructive
  • Older adults
  • Quality of life
  • Rapid eye movement
  • Sleep
  • Sleep apnea
  • Sleep apnea syndromes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in osteoporotic fractures in men (MrOS) sleep study. / Khan, Akram; Harrison, Stephanie L.; Kezirian, Eric J.; Ancoli-Israel, Sonia; O'Hearn, Daniel; Orwoll, Eric; Redline, Susan; Ensrud, Kristine; Stone, Katie L.

In: Journal of Clinical Sleep Medicine, Vol. 9, No. 3, 2013.

Research output: Contribution to journalArticle

Khan, Akram ; Harrison, Stephanie L. ; Kezirian, Eric J. ; Ancoli-Israel, Sonia ; O'Hearn, Daniel ; Orwoll, Eric ; Redline, Susan ; Ensrud, Kristine ; Stone, Katie L. / Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in osteoporotic fractures in men (MrOS) sleep study. In: Journal of Clinical Sleep Medicine. 2013 ; Vol. 9, No. 3.
@article{ff7fc01e138e49c18f0522dfaa64232f,
title = "Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in osteoporotic fractures in men (MrOS) sleep study",
abstract = "Study Objectives: Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and qualityof life in a community-based cohort of men ≥ 65 years-old. Design, Intervention and Measurements: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) <15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (<5 [referent group], 5 to <15, 15 to <30, and ≥ 30). Daytime somnolence, sleep-related quality of life, sleep disturbance, general quality of life, depressive symptoms, and health status were quantified using Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), Geriatric Depression Scale-15 (GDS), and self-perceived health status, respectively. Results: Prevalence of REM-predominant OSA (AHI-REM ≥ 5) was 42.8{\%} if OSA was defined as AHI ≥ 15 and 14.4{\%} if OSA was defined as AHI ≥ 5. Higher AHI-REM was associated with polysomnographic indices of poorer sleep architecture (reduced total sleep time, sleep effi ciency, REM sleep duration and proportion). Adjusting for age, BMI, and study site, higher AHI-REM was not associated with subjective sleep measures (ESS, FOSQ, PSQI), lower quality of life (SF-12), or greater depressive symptoms (GDS). Conclusions: In a community-based sample of older adult men ≥ 65 years-old, REM-predominant OSA was highly prevalent and was associated with objective indices of poorer sleep quality on polysomnography but not with subjective measures of daytime sleepiness or quality of life.",
keywords = "Disorders of excessive somnolence, Epidemiology, Obstructive, Older adults, Quality of life, Rapid eye movement, Sleep, Sleep apnea, Sleep apnea syndromes",
author = "Akram Khan and Harrison, {Stephanie L.} and Kezirian, {Eric J.} and Sonia Ancoli-Israel and Daniel O'Hearn and Eric Orwoll and Susan Redline and Kristine Ensrud and Stone, {Katie L.}",
year = "2013",
doi = "10.5664/jcsm.2474",
language = "English (US)",
volume = "9",
journal = "Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
number = "3",

}

TY - JOUR

T1 - Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in osteoporotic fractures in men (MrOS) sleep study

AU - Khan, Akram

AU - Harrison, Stephanie L.

AU - Kezirian, Eric J.

AU - Ancoli-Israel, Sonia

AU - O'Hearn, Daniel

AU - Orwoll, Eric

AU - Redline, Susan

AU - Ensrud, Kristine

AU - Stone, Katie L.

PY - 2013

Y1 - 2013

N2 - Study Objectives: Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and qualityof life in a community-based cohort of men ≥ 65 years-old. Design, Intervention and Measurements: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) <15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (<5 [referent group], 5 to <15, 15 to <30, and ≥ 30). Daytime somnolence, sleep-related quality of life, sleep disturbance, general quality of life, depressive symptoms, and health status were quantified using Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), Geriatric Depression Scale-15 (GDS), and self-perceived health status, respectively. Results: Prevalence of REM-predominant OSA (AHI-REM ≥ 5) was 42.8% if OSA was defined as AHI ≥ 15 and 14.4% if OSA was defined as AHI ≥ 5. Higher AHI-REM was associated with polysomnographic indices of poorer sleep architecture (reduced total sleep time, sleep effi ciency, REM sleep duration and proportion). Adjusting for age, BMI, and study site, higher AHI-REM was not associated with subjective sleep measures (ESS, FOSQ, PSQI), lower quality of life (SF-12), or greater depressive symptoms (GDS). Conclusions: In a community-based sample of older adult men ≥ 65 years-old, REM-predominant OSA was highly prevalent and was associated with objective indices of poorer sleep quality on polysomnography but not with subjective measures of daytime sleepiness or quality of life.

AB - Study Objectives: Assess the association between REM predominant obstructive sleep apnea (OSA), sleepiness, and qualityof life in a community-based cohort of men ≥ 65 years-old. Design, Intervention and Measurements: A cross-sectional analysis of 2,765 subjects from the Outcomes of Sleep Disorders in Older Men (MrOS Sleep) Study was performed to identify subjects with an apnea hypopnea index (AHI) <15 (n = 2,044). Subjects were divided into groups based on the AHI in REM sleep (<5 [referent group], 5 to <15, 15 to <30, and ≥ 30). Daytime somnolence, sleep-related quality of life, sleep disturbance, general quality of life, depressive symptoms, and health status were quantified using Epworth Sleepiness Scale (ESS), Functional Outcomes of Sleep Questionnaire (FOSQ), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), Geriatric Depression Scale-15 (GDS), and self-perceived health status, respectively. Results: Prevalence of REM-predominant OSA (AHI-REM ≥ 5) was 42.8% if OSA was defined as AHI ≥ 15 and 14.4% if OSA was defined as AHI ≥ 5. Higher AHI-REM was associated with polysomnographic indices of poorer sleep architecture (reduced total sleep time, sleep effi ciency, REM sleep duration and proportion). Adjusting for age, BMI, and study site, higher AHI-REM was not associated with subjective sleep measures (ESS, FOSQ, PSQI), lower quality of life (SF-12), or greater depressive symptoms (GDS). Conclusions: In a community-based sample of older adult men ≥ 65 years-old, REM-predominant OSA was highly prevalent and was associated with objective indices of poorer sleep quality on polysomnography but not with subjective measures of daytime sleepiness or quality of life.

KW - Disorders of excessive somnolence

KW - Epidemiology

KW - Obstructive

KW - Older adults

KW - Quality of life

KW - Rapid eye movement

KW - Sleep

KW - Sleep apnea

KW - Sleep apnea syndromes

UR - http://www.scopus.com/inward/record.url?scp=84875105638&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875105638&partnerID=8YFLogxK

U2 - 10.5664/jcsm.2474

DO - 10.5664/jcsm.2474

M3 - Article

C2 - 23493839

AN - SCOPUS:84875105638

VL - 9

JO - Journal of Clinical Sleep Medicine

JF - Journal of Clinical Sleep Medicine

SN - 1550-9389

IS - 3

ER -