Obstructive sleep apnea and metabolic bone disease: Insights into the relationship between bone and sleep

Christine M. Swanson, Steven A. Shea, Katie L. Stone, Jane A. Cauley, Clifford J. Rosen, Susan Redline, Gerard Karsenty, Eric S. Orwoll

Research output: Contribution to journalReview article

42 Scopus citations

Abstract

Obstructive sleep apnea (OSA) and low bone mass are two prevalent conditions, particularly among older adults - a section of the U.S. population that is expected to grow dramatically over the coming years. OSA, the most common form of sleep-disordered breathing, has been linked to multiple cardiovascular, metabolic, hormonal, and inflammatory derangements and may have adverse effects on bone. However, little is known about how OSA (including the associated hypoxia and sleep loss) affects bone metabolism. In order to gain insight into the relationship between sleep and bone, we review the growing information on OSA and metabolic bone disease and discuss the pathophysiological mechanisms by which OSA may affect bone metabolism/architecture.

Original languageEnglish (US)
Pages (from-to)199-211
Number of pages13
JournalJournal of Bone and Mineral Research
Volume30
Issue number2
DOIs
StatePublished - Feb 1 2015

Keywords

  • Bone Mineral Density (BMD)
  • Bone remodeling
  • Circadian rhythm
  • Fracture
  • Nocturnal hypoxia
  • Obstructive Sleep Apnea (OSA)
  • Review
  • Sleep
  • Sleep loss

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Fingerprint Dive into the research topics of 'Obstructive sleep apnea and metabolic bone disease: Insights into the relationship between bone and sleep'. Together they form a unique fingerprint.

  • Cite this