Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer

Lionel L. Bañez, Robert J. Hamilton, Alan W. Partin, Robin T. Vollmer, Leon Sun, Carmen Rodriguez, Yiting Wang, Martha K. Terris, William J. Aronson, Joseph C. Presti, Christopher J. Kane, Christopher Amling, Judd W. Moul, Stephen J. Freedland

Research output: Contribution to journalArticle

238 Citations (Scopus)

Abstract

Context: Recent studies have suggested that obese men have lower serum prostate-specific antigen (PSA) concentrations than nonobese men. Because men with higher body mass index (BMI) have greater circulating plasma volumes, lower PSA concentrations among obese men may be due to hemodilution. Objective: To determine the association between hemodilution and PSA concentration in obese men with prostate cancer. Design, Setting, and Participants: Retrospective study of men who underwent radical prostatectomy for prostate adenocarcinoma from 1988 to 2006, using data from the databases of the Shared Equal Access Regional Cancer Hospital (n=1373), Duke Prostate Center (n=1974), and Johns Hopkins Hospital (n=10 287). Multivariate linear regression models adjusting for clinicopathological characteristics were used to analyze the main outcome measures. Main Outcome Measures: Associations between BMI and mean adjusted PSA concentrations, mean plasma volume, and mean adjusted PSA mass (total circulating PSA protein, calculated as PSA concentration multiplied by plasma volume), assessed by determining P values for trend. Results: After controlling for clinicopathological characteristics, higher BMI was significantly associated with higher plasma volume (P

Original languageEnglish (US)
Pages (from-to)2275-2280
Number of pages6
JournalJournal of the American Medical Association
Volume298
Issue number19
DOIs
StatePublished - Nov 21 2007
Externally publishedYes

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Hemodilution
Prostate-Specific Antigen
Prostatic Neoplasms
Obesity
Plasma Volume
Body Mass Index
Prostate
Linear Models
Outcome Assessment (Health Care)
Cancer Care Facilities
Prostatectomy
Adenocarcinoma
Retrospective Studies
Databases
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Bañez, L. L., Hamilton, R. J., Partin, A. W., Vollmer, R. T., Sun, L., Rodriguez, C., ... Freedland, S. J. (2007). Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. Journal of the American Medical Association, 298(19), 2275-2280. https://doi.org/10.1001/jama.298.19.2275

Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. / Bañez, Lionel L.; Hamilton, Robert J.; Partin, Alan W.; Vollmer, Robin T.; Sun, Leon; Rodriguez, Carmen; Wang, Yiting; Terris, Martha K.; Aronson, William J.; Presti, Joseph C.; Kane, Christopher J.; Amling, Christopher; Moul, Judd W.; Freedland, Stephen J.

In: Journal of the American Medical Association, Vol. 298, No. 19, 21.11.2007, p. 2275-2280.

Research output: Contribution to journalArticle

Bañez, LL, Hamilton, RJ, Partin, AW, Vollmer, RT, Sun, L, Rodriguez, C, Wang, Y, Terris, MK, Aronson, WJ, Presti, JC, Kane, CJ, Amling, C, Moul, JW & Freedland, SJ 2007, 'Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer', Journal of the American Medical Association, vol. 298, no. 19, pp. 2275-2280. https://doi.org/10.1001/jama.298.19.2275
Bañez, Lionel L. ; Hamilton, Robert J. ; Partin, Alan W. ; Vollmer, Robin T. ; Sun, Leon ; Rodriguez, Carmen ; Wang, Yiting ; Terris, Martha K. ; Aronson, William J. ; Presti, Joseph C. ; Kane, Christopher J. ; Amling, Christopher ; Moul, Judd W. ; Freedland, Stephen J. / Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. In: Journal of the American Medical Association. 2007 ; Vol. 298, No. 19. pp. 2275-2280.
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