Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention: A randomized controlled study

Rehana Lovely, Jobayer Hossain, Jonathen P. Ramsey, Venugopal Komakula, Donald George, David Farrell, Prabhakaran Balagopal

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To determine if elevated plasma γ′-fibrinogen, typically involved in the formation of fibrinolysis-resistant clots, confers an increased risk for cardiovascular disease (CVD) and thrombosis in children as it does in adults. Although obesity-related hyperfibrinogenemia is frequently reported in children, the role of γ′ fibrinogen and its response to physical activity-based lifestyle are less clear in this population. Study design: In a randomized controlled 3-month physical activity-based lifestyle intervention, γ′ fibrinogen concentration was measured in 21 children (aged 14-18 years; Tanner stage > IV), including 15 in the obese group and 6 in the normal weight group, with body mass index percentiles for age and sex of >95 and 2 = 0.9; P

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalJournal of Pediatrics
Volume163
Issue number2
DOIs
StatePublished - Aug 2013

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Fibrinogen
Life Style
Obesity
Exercise
Fibrinolysis
Body Mass Index
Thrombosis
Cardiovascular Diseases
Weights and Measures
Population

Keywords

  • BMI
  • Body mass index
  • Bovine serum albumin
  • BSA
  • C-reactive protein
  • Cardiovascular disease
  • CRP
  • CVD
  • DEXA
  • Dual-energy X-ray absorptiometry
  • HOMA-IR
  • Homeostasis model of assessment-insulin resistance
  • IL
  • Interleukin
  • PBS
  • Phosphate-buffered saline

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention : A randomized controlled study. / Lovely, Rehana; Hossain, Jobayer; Ramsey, Jonathen P.; Komakula, Venugopal; George, Donald; Farrell, David; Balagopal, Prabhakaran.

In: Journal of Pediatrics, Vol. 163, No. 2, 08.2013, p. 333-338.

Research output: Contribution to journalArticle

Lovely, Rehana ; Hossain, Jobayer ; Ramsey, Jonathen P. ; Komakula, Venugopal ; George, Donald ; Farrell, David ; Balagopal, Prabhakaran. / Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention : A randomized controlled study. In: Journal of Pediatrics. 2013 ; Vol. 163, No. 2. pp. 333-338.
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