Obesity-related increased γ' fibrinogen concentration in children and its reduction by a physical activity-based lifestyle intervention: A randomized controlled study

Rehana Lovely, Jobayer Hossain, Jonathen P. Ramsey, Venugopal Komakula, Donald George, David H. Farrell, Prabhakaran Balagopal

Research output: Contribution to journalArticle

13 Scopus citations


Objective: To determine if elevated plasma γ′-fibrinogen, typically involved in the formation of fibrinolysis-resistant clots, confers an increased risk for cardiovascular disease (CVD) and thrombosis in children as it does in adults. Although obesity-related hyperfibrinogenemia is frequently reported in children, the role of γ′ fibrinogen and its response to physical activity-based lifestyle are less clear in this population. Study design: In a randomized controlled 3-month physical activity-based lifestyle intervention, γ′ fibrinogen concentration was measured in 21 children (aged 14-18 years; Tanner stage > IV), including 15 in the obese group and 6 in the normal weight group, with body mass index percentiles for age and sex of >95 and <85, respectively. Results: The relationships between γ′ fibrinogen and other risk factors for CVD, such as markers of insulin resistance and subclinical inflammation, along with body composition (as measured by dual-energy X-ray absortiometry), were assessed before and after the intervention. γ′ fibrinogen concentration was higher in the obese group compared with the normal weight group (P <.05) and was correlated with other risk factors for CVD (adjusted R2 = 0.9; P <.05), and insulin emerged as the major predictor of γ′ fibrinogen. The intervention reduced γ′-fibrinogen concentration (P <.05). Conclusion: Our data reveal: (1) elevated γ′ fibrinogen concentrations in obese insulin-resistant children compared with normal lean controls; (2) a relationship between γ′ fibrinogen and other CVD risk factors; and (3) physical activity-induced reduction in γ′ fibrinogen in obese children.

Original languageEnglish (US)
Pages (from-to)333-338
Number of pages6
JournalJournal of Pediatrics
Issue number2
StatePublished - Aug 1 2013



  • BMI
  • BSA
  • Body mass index
  • Bovine serum albumin
  • C-reactive protein
  • CRP
  • CVD
  • Cardiovascular disease
  • DEXA
  • Dual-energy X-ray absorptiometry
  • Homeostasis model of assessment-insulin resistance
  • IL
  • Interleukin
  • PBS
  • Phosphate-buffered saline

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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