Obesity is associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy: Results from the SEARCH database

Christopher J. Keto, William J. Aronson, Martha K. Terris, Joseph C. Presti, Christopher J. Kane, Christopher Amling, Stephen J. Freedland

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Objective To investigate whether obesity predicts poor outcomes in men starting androgen deprivation therapy (ADT) before metastasis, since previous studies found worse outcomes after surgery and radiation for obese men. METHODS A retrospective review was carried out of 287 men in the SEARCH database treated with radical prostatectomy between 1988 and 2009. Body mass index (BMI) was categorized to

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalBJU International
Volume110
Issue number4
DOIs
StatePublished - Aug 2012

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Castration
Prostatectomy
Androgens
Obesity
Databases
Neoplasm Metastasis
Body Mass Index
Therapeutics
Radiation

Keywords

  • androgen deprivation therapy
  • castration-resistant prostate cancer
  • metastases
  • obesity
  • prostate cancer

ASJC Scopus subject areas

  • Urology

Cite this

Obesity is associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy : Results from the SEARCH database. / Keto, Christopher J.; Aronson, William J.; Terris, Martha K.; Presti, Joseph C.; Kane, Christopher J.; Amling, Christopher; Freedland, Stephen J.

In: BJU International, Vol. 110, No. 4, 08.2012, p. 492-498.

Research output: Contribution to journalArticle

Keto, Christopher J. ; Aronson, William J. ; Terris, Martha K. ; Presti, Joseph C. ; Kane, Christopher J. ; Amling, Christopher ; Freedland, Stephen J. / Obesity is associated with castration-resistant disease and metastasis in men treated with androgen deprivation therapy after radical prostatectomy : Results from the SEARCH database. In: BJU International. 2012 ; Vol. 110, No. 4. pp. 492-498.
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