TY - JOUR
T1 - Obesity increases and physical activity decreases lower urinary tract symptom risk in older men
T2 - The osteoporotic fractures in men study
AU - Parsons, J. Kellogg
AU - Messer, Karen
AU - White, Martha
AU - Barrett-Connor, Elizabeth
AU - Bauer, Douglas C.
AU - Marshall, Lynn M.
N1 - Funding Information:
Funding/Support and role of the sponsor: The Osteoporotic Fractures in Men (MrOS) Study is supported by the National Institutes of Health. The following institutes provide support: the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute on Aging (NIA), the National Center for Research Resources (NCRR), and the NIH Roadmap for Medical Research under the following grant numbers: U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01-AG027810, and UL1 RR024140. Funding was also provided by the Urologic Diseases of America Project (N01-DK-7-0003) and NIDDK R21DK083675. NIAMS, NIA, NCRR, and the NIH Roadmap for Medical Research provided support for the design and conduct of the study; collection, management, and interpretation of the data; and approval of the manuscript. The National Institute of Diabetes and Digestive and Kidney Diseases provided support for the design and statistical analyses.
PY - 2011/12
Y1 - 2011/12
N2 - Background: Two potential targets for preventing chronic lower urinary tract symptoms (LUTS) in older men are obesity and physical activity. Objective: To examine associations of adiposity and physical activity with incident LUTS in community-dwelling older men. Design, setting, and participants: The Osteoporotic Fractures in Men Study (MrOS) is a prospective cohort of men ≥65 yr of age. MrOS participants without LUTS and a history of LUTS treatment at baseline were included in this analysis. Measurements: Adiposity was measured with body mass index (BMI), physical activity with the Physical Activity Scale for the Elderly (PASE) and self-report of daily walking, and LUTS with the American Urological Association Symptom Index. Results and limitations: The mean age (standard deviation [SD]) of the 1695 participants was 72 (5) yr at baseline. At a mean (SD) follow-up of 4.6 (0.5) yr, 524 (31%) of men reported incident LUTS. In multivariate analyses, compared with men of normal weight at baseline (BMI <25 kg/m 2), overweight (BMI: 25.0-29.9 kg/m 2) and obese (≥30 kg/m 2)men were 29% (adjusted odds ratio [OR adj]: 1.29; 95% confidence interval [CI], 1.00-1.68) and 41% (OR adj: 1.41; 95% CI, 1.03-1.93) more likely to develop LUTS, respectively. Men in the highest quartile of physical activity were 29% (OR adj: 0.71; 95% CI, 0.53-0.97) and those who walked daily 20% (OR adj: 0.80; 95% CI, 0.65-0.98) less likely than their sedentary peers to develop LUTS, adjusting for BMI. The homogeneous composition of MrOS potentially diminishes the external validity of these results. Conclusions: In older men, obesity and higher physical activity are associated with increased and decreased risks of incident LUTS, respectively. Prevention of chronic urinary symptoms represents another potential health benefit of exercise in elderly men.
AB - Background: Two potential targets for preventing chronic lower urinary tract symptoms (LUTS) in older men are obesity and physical activity. Objective: To examine associations of adiposity and physical activity with incident LUTS in community-dwelling older men. Design, setting, and participants: The Osteoporotic Fractures in Men Study (MrOS) is a prospective cohort of men ≥65 yr of age. MrOS participants without LUTS and a history of LUTS treatment at baseline were included in this analysis. Measurements: Adiposity was measured with body mass index (BMI), physical activity with the Physical Activity Scale for the Elderly (PASE) and self-report of daily walking, and LUTS with the American Urological Association Symptom Index. Results and limitations: The mean age (standard deviation [SD]) of the 1695 participants was 72 (5) yr at baseline. At a mean (SD) follow-up of 4.6 (0.5) yr, 524 (31%) of men reported incident LUTS. In multivariate analyses, compared with men of normal weight at baseline (BMI <25 kg/m 2), overweight (BMI: 25.0-29.9 kg/m 2) and obese (≥30 kg/m 2)men were 29% (adjusted odds ratio [OR adj]: 1.29; 95% confidence interval [CI], 1.00-1.68) and 41% (OR adj: 1.41; 95% CI, 1.03-1.93) more likely to develop LUTS, respectively. Men in the highest quartile of physical activity were 29% (OR adj: 0.71; 95% CI, 0.53-0.97) and those who walked daily 20% (OR adj: 0.80; 95% CI, 0.65-0.98) less likely than their sedentary peers to develop LUTS, adjusting for BMI. The homogeneous composition of MrOS potentially diminishes the external validity of these results. Conclusions: In older men, obesity and higher physical activity are associated with increased and decreased risks of incident LUTS, respectively. Prevention of chronic urinary symptoms represents another potential health benefit of exercise in elderly men.
KW - BPH
KW - Benign prostatic hyperplasia
KW - Epidemiology
KW - Exercise
KW - IPSS
KW - LUTS
KW - Obesity
KW - Physical activity
KW - Prostate
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U2 - 10.1016/j.eururo.2011.07.040
DO - 10.1016/j.eururo.2011.07.040
M3 - Article
C2 - 21802828
AN - SCOPUS:80255141912
SN - 0302-2838
VL - 60
SP - 1173
EP - 1180
JO - European Urology
JF - European Urology
IS - 6
ER -