Obesity

A transgenerational problem linked to nutrition during pregnancy

Antonio Frias, Kevin Grove

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.

Original languageEnglish (US)
Pages (from-to)472-478
Number of pages7
JournalSeminars in Reproductive Medicine
Volume30
Issue number6
DOIs
StatePublished - 2012

Fingerprint

Prenatal Nutritional Physiological Phenomena
Obesity
Stillbirth
Mothers
Obstetrics
Prenatal Care
Gestational Diabetes
Pediatric Obesity
Adiposity
Fetal Development
Pre-Eclampsia

Keywords

  • high fat diet
  • obesity
  • placenta
  • pregnancy
  • programming

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Obesity : A transgenerational problem linked to nutrition during pregnancy. / Frias, Antonio; Grove, Kevin.

In: Seminars in Reproductive Medicine, Vol. 30, No. 6, 2012, p. 472-478.

Research output: Contribution to journalArticle

@article{2b5d1965afde44baa68cf0088c572f7c,
title = "Obesity: A transgenerational problem linked to nutrition during pregnancy",
abstract = "The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.",
keywords = "high fat diet, obesity, placenta, pregnancy, programming",
author = "Antonio Frias and Kevin Grove",
year = "2012",
doi = "10.1055/s-0032-1328875",
language = "English (US)",
volume = "30",
pages = "472--478",
journal = "Seminars in Reproductive Medicine",
issn = "1526-8004",
publisher = "Thieme Medical Publishers",
number = "6",

}

TY - JOUR

T1 - Obesity

T2 - A transgenerational problem linked to nutrition during pregnancy

AU - Frias, Antonio

AU - Grove, Kevin

PY - 2012

Y1 - 2012

N2 - The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.

AB - The increased obstetric risks of maternal obesity have been well described. These include increased risks of gestational diabetes mellitus, preeclampsia, stillbirth, and cesarean delivery. The fetal/neonatal consequences of prenatal maternal obesity have received less attention. In addition to an increased risk of stillbirth, the fetal/neonatal consequences include increased adiposity and a metabolic status that increases the lifetime risk of obesity and diabetes. This review focuses on the clinical obstetric consequences of maternal obesity and highlights recent mechanistic insights on fetal programming as well as evidence suggesting that prenatal care provides a unique opportunity to ameliorate these risks and decrease the cycle of childhood obesity.

KW - high fat diet

KW - obesity

KW - placenta

KW - pregnancy

KW - programming

UR - http://www.scopus.com/inward/record.url?scp=84867560419&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867560419&partnerID=8YFLogxK

U2 - 10.1055/s-0032-1328875

DO - 10.1055/s-0032-1328875

M3 - Article

VL - 30

SP - 472

EP - 478

JO - Seminars in Reproductive Medicine

JF - Seminars in Reproductive Medicine

SN - 1526-8004

IS - 6

ER -