TY - JOUR
T1 - Nutritional support for Crohn's disease
AU - Song, Howard K.
AU - Buzby, Gordon P.
PY - 2001
Y1 - 2001
N2 - Nutritional considerations are intimately associated with Crohn's disease. Food antigens and dietary factors have been postulated to have a role in its pathogenesis, and the disease leads to decreased absorptive capacity of the gut. Malnutrition is a common manifestation of Crohn's disease, necessitating close monitoring of patients and rapid nutritional intervention to correct deficiencies. The indications for supportive nutritional therapy are well defined and include measures to improve patients' nutritional status and growth and development; decrease perioperative complications; and manage complications of Crohn's disease, including enterocutaneous fistulas and short-bowel syndrome. Nutritional therapy as a first-line treatment of Crohn's disease is controversial. Although enteral nutrition has been found to have efficacy in this setting, steroid therapy is the gold standard treatment of acute Crohn's disease, with enteral nutrition reserved for steroid-resistant or steroid-intolerant patients. An emerging use of supplementary enteral nutrition is in the maintenance of Crohn's disease remission. Interestingly, this benefit seems to be associated with improvement in patients' nutrition, suggesting a relationship between nutritional status and disease activity. Further insight into this field, including the potential of micronutrients to promote trophic, healing, and immunomodulatory effects on the gut, may lead to novel and efficacious treatments of this disease.
AB - Nutritional considerations are intimately associated with Crohn's disease. Food antigens and dietary factors have been postulated to have a role in its pathogenesis, and the disease leads to decreased absorptive capacity of the gut. Malnutrition is a common manifestation of Crohn's disease, necessitating close monitoring of patients and rapid nutritional intervention to correct deficiencies. The indications for supportive nutritional therapy are well defined and include measures to improve patients' nutritional status and growth and development; decrease perioperative complications; and manage complications of Crohn's disease, including enterocutaneous fistulas and short-bowel syndrome. Nutritional therapy as a first-line treatment of Crohn's disease is controversial. Although enteral nutrition has been found to have efficacy in this setting, steroid therapy is the gold standard treatment of acute Crohn's disease, with enteral nutrition reserved for steroid-resistant or steroid-intolerant patients. An emerging use of supplementary enteral nutrition is in the maintenance of Crohn's disease remission. Interestingly, this benefit seems to be associated with improvement in patients' nutrition, suggesting a relationship between nutritional status and disease activity. Further insight into this field, including the potential of micronutrients to promote trophic, healing, and immunomodulatory effects on the gut, may lead to novel and efficacious treatments of this disease.
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U2 - 10.1016/S0039-6109(05)70275-9
DO - 10.1016/S0039-6109(05)70275-9
M3 - Article
C2 - 11218158
AN - SCOPUS:0035129663
SN - 0039-6109
VL - 81
SP - 103
EP - 115
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 1
ER -