Nutritional biomarkers in Alzheimer's disease

The association between carotenoids, n-3 fatty acids, and dementia severity

Wei Wang, Lynne Shinto, William E. Connor, Joseph Quinn

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Carotenoids are fat-soluble antioxidants that may protect polyunsaturated fatty acids, such as n-3 fatty acids from oxidation, and are potentially important for Alzheimer's disease (AD) prevention and treatment. Fasting plasma carotenoids were measured in 36 AD subjects and 10 control subjects by HPLC. Correlations between plasma carotenoid levels, red blood cell (RBC) n-3 fatty acids, and dementia severity were examined in AD patients. Moderately severe AD patients (MMSE=16-19) had much lower plasma levels of two major carotenoids: lutein and beta-carotene, compared to mild AD patients (MMSE=24-27) or controls. Among AD patients, variables (lutein, beta-carotene, RBC docosahexaenoic acid (DHA) and LDL-cholesterol) were significantly correlated with MMSE. A lower MMSE score was associated with lower lutein, beta-carotene and RBC DHA levels, and a higher LDL-cholesterol level. These variables explained the majority of variation in dementia severity (55% of variance in MMSE). Lutein, beta-carotene and beta-cryptoxanthin were positively correlated with RBC DHA in AD patients. The association between higher carotenoids levels and DHA and higher MMSE scores, supports a protective role of both types of nutrients in AD. These findings suggest targeting multiple specific nutrients, lutein, beta-carotene, and DHA in strategies to slow the rate of cognitive decline.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalJournal of Alzheimer's Disease
Volume13
Issue number1
StatePublished - 2008

Fingerprint

Omega-3 Fatty Acids
Carotenoids
Lutein
Dementia
Docosahexaenoic Acids
Alzheimer Disease
beta Carotene
Biomarkers
Erythrocytes
LDL Cholesterol
Food
Hypercholesterolemia
Unsaturated Fatty Acids
Fasting
Antioxidants
Fats
High Pressure Liquid Chromatography

Keywords

  • Alzheimer's disease
  • Beta-carotene
  • Carotenoids
  • Dementia
  • Docosahexaenoic acid
  • Lutein

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

Cite this

Nutritional biomarkers in Alzheimer's disease : The association between carotenoids, n-3 fatty acids, and dementia severity. / Wang, Wei; Shinto, Lynne; Connor, William E.; Quinn, Joseph.

In: Journal of Alzheimer's Disease, Vol. 13, No. 1, 2008, p. 31-38.

Research output: Contribution to journalArticle

@article{288e80646dc443858713723b739d68b6,
title = "Nutritional biomarkers in Alzheimer's disease: The association between carotenoids, n-3 fatty acids, and dementia severity",
abstract = "Carotenoids are fat-soluble antioxidants that may protect polyunsaturated fatty acids, such as n-3 fatty acids from oxidation, and are potentially important for Alzheimer's disease (AD) prevention and treatment. Fasting plasma carotenoids were measured in 36 AD subjects and 10 control subjects by HPLC. Correlations between plasma carotenoid levels, red blood cell (RBC) n-3 fatty acids, and dementia severity were examined in AD patients. Moderately severe AD patients (MMSE=16-19) had much lower plasma levels of two major carotenoids: lutein and beta-carotene, compared to mild AD patients (MMSE=24-27) or controls. Among AD patients, variables (lutein, beta-carotene, RBC docosahexaenoic acid (DHA) and LDL-cholesterol) were significantly correlated with MMSE. A lower MMSE score was associated with lower lutein, beta-carotene and RBC DHA levels, and a higher LDL-cholesterol level. These variables explained the majority of variation in dementia severity (55{\%} of variance in MMSE). Lutein, beta-carotene and beta-cryptoxanthin were positively correlated with RBC DHA in AD patients. The association between higher carotenoids levels and DHA and higher MMSE scores, supports a protective role of both types of nutrients in AD. These findings suggest targeting multiple specific nutrients, lutein, beta-carotene, and DHA in strategies to slow the rate of cognitive decline.",
keywords = "Alzheimer's disease, Beta-carotene, Carotenoids, Dementia, Docosahexaenoic acid, Lutein",
author = "Wei Wang and Lynne Shinto and Connor, {William E.} and Joseph Quinn",
year = "2008",
language = "English (US)",
volume = "13",
pages = "31--38",
journal = "Journal of Alzheimer's Disease",
issn = "1387-2877",
publisher = "IOS Press",
number = "1",

}

TY - JOUR

T1 - Nutritional biomarkers in Alzheimer's disease

T2 - The association between carotenoids, n-3 fatty acids, and dementia severity

AU - Wang, Wei

AU - Shinto, Lynne

AU - Connor, William E.

AU - Quinn, Joseph

PY - 2008

Y1 - 2008

N2 - Carotenoids are fat-soluble antioxidants that may protect polyunsaturated fatty acids, such as n-3 fatty acids from oxidation, and are potentially important for Alzheimer's disease (AD) prevention and treatment. Fasting plasma carotenoids were measured in 36 AD subjects and 10 control subjects by HPLC. Correlations between plasma carotenoid levels, red blood cell (RBC) n-3 fatty acids, and dementia severity were examined in AD patients. Moderately severe AD patients (MMSE=16-19) had much lower plasma levels of two major carotenoids: lutein and beta-carotene, compared to mild AD patients (MMSE=24-27) or controls. Among AD patients, variables (lutein, beta-carotene, RBC docosahexaenoic acid (DHA) and LDL-cholesterol) were significantly correlated with MMSE. A lower MMSE score was associated with lower lutein, beta-carotene and RBC DHA levels, and a higher LDL-cholesterol level. These variables explained the majority of variation in dementia severity (55% of variance in MMSE). Lutein, beta-carotene and beta-cryptoxanthin were positively correlated with RBC DHA in AD patients. The association between higher carotenoids levels and DHA and higher MMSE scores, supports a protective role of both types of nutrients in AD. These findings suggest targeting multiple specific nutrients, lutein, beta-carotene, and DHA in strategies to slow the rate of cognitive decline.

AB - Carotenoids are fat-soluble antioxidants that may protect polyunsaturated fatty acids, such as n-3 fatty acids from oxidation, and are potentially important for Alzheimer's disease (AD) prevention and treatment. Fasting plasma carotenoids were measured in 36 AD subjects and 10 control subjects by HPLC. Correlations between plasma carotenoid levels, red blood cell (RBC) n-3 fatty acids, and dementia severity were examined in AD patients. Moderately severe AD patients (MMSE=16-19) had much lower plasma levels of two major carotenoids: lutein and beta-carotene, compared to mild AD patients (MMSE=24-27) or controls. Among AD patients, variables (lutein, beta-carotene, RBC docosahexaenoic acid (DHA) and LDL-cholesterol) were significantly correlated with MMSE. A lower MMSE score was associated with lower lutein, beta-carotene and RBC DHA levels, and a higher LDL-cholesterol level. These variables explained the majority of variation in dementia severity (55% of variance in MMSE). Lutein, beta-carotene and beta-cryptoxanthin were positively correlated with RBC DHA in AD patients. The association between higher carotenoids levels and DHA and higher MMSE scores, supports a protective role of both types of nutrients in AD. These findings suggest targeting multiple specific nutrients, lutein, beta-carotene, and DHA in strategies to slow the rate of cognitive decline.

KW - Alzheimer's disease

KW - Beta-carotene

KW - Carotenoids

KW - Dementia

KW - Docosahexaenoic acid

KW - Lutein

UR - http://www.scopus.com/inward/record.url?scp=40549113353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549113353&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 31

EP - 38

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 1

ER -