Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging

Gene Bowman, Lisa Silbert, Diane Howieson, Hiroko Dodge, M. G. Traber, B. Frei, Jeffrey Kaye, Jackilen (Jackie) Shannon, Joseph Quinn

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders. Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. Results: Mean age was 87 ± 10 years and 62% of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine ω-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine ω-3 pattern and white matter hyperintensity volume. Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population.

Original languageEnglish (US)
Pages (from-to)241-249
Number of pages9
JournalNeurology
Volume78
Issue number4
DOIs
StatePublished - Jan 24 2012

Fingerprint

Cognition
Biomarkers
Food
Brain
Thiamine
Health
Principal Component Analysis
Folic Acid
Psychometrics
Neuroimaging
Dementia
Cohort Studies
Fatty Acids
Fats
Depression
Diet
Cognitive Function
Plasma
Population

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. / Bowman, Gene; Silbert, Lisa; Howieson, Diane; Dodge, Hiroko; Traber, M. G.; Frei, B.; Kaye, Jeffrey; Shannon, Jackilen (Jackie); Quinn, Joseph.

In: Neurology, Vol. 78, No. 4, 24.01.2012, p. 241-249.

Research output: Contribution to journalArticle

Bowman, Gene ; Silbert, Lisa ; Howieson, Diane ; Dodge, Hiroko ; Traber, M. G. ; Frei, B. ; Kaye, Jeffrey ; Shannon, Jackilen (Jackie) ; Quinn, Joseph. / Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging. In: Neurology. 2012 ; Vol. 78, No. 4. pp. 241-249.
@article{25dbf264a43444f3949211383503bc4c,
title = "Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging",
abstract = "Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders. Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. Results: Mean age was 87 ± 10 years and 62{\%} of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine ω-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine ω-3 pattern and white matter hyperintensity volume. Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population.",
author = "Gene Bowman and Lisa Silbert and Diane Howieson and Hiroko Dodge and Traber, {M. G.} and B. Frei and Jeffrey Kaye and Shannon, {Jackilen (Jackie)} and Joseph Quinn",
year = "2012",
month = "1",
day = "24",
doi = "10.1212/WNL.0b013e3182436598",
language = "English (US)",
volume = "78",
pages = "241--249",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Nutrient biomarker patterns, cognitive function, and MRI measures of brain aging

AU - Bowman, Gene

AU - Silbert, Lisa

AU - Howieson, Diane

AU - Dodge, Hiroko

AU - Traber, M. G.

AU - Frei, B.

AU - Kaye, Jeffrey

AU - Shannon, Jackilen (Jackie)

AU - Quinn, Joseph

PY - 2012/1/24

Y1 - 2012/1/24

N2 - Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders. Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. Results: Mean age was 87 ± 10 years and 62% of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine ω-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine ω-3 pattern and white matter hyperintensity volume. Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population.

AB - Objective: To examine the cross-sectional relationship between nutrient status and psychometric and imaging indices of brain health in dementia-free elders. Methods: Thirty plasma biomarkers of diet were assayed in the Oregon Brain Aging Study cohort (n = 104). Principal component analysis constructed nutrient biomarker patterns (NBPs) and regression models assessed the relationship of these with cognitive and MRI outcomes. Results: Mean age was 87 ± 10 years and 62% of subjects were female. Two NBPs associated with more favorable cognitive and MRI measures: one high in plasma vitamins B (B1, B2, B6, folate, and B12), C, D, and E, and another high in plasma marine ω-3 fatty acids. A third pattern characterized by high trans fat was associated with less favorable cognitive function and less total cerebral brain volume. Depression attenuated the relationship between the marine ω-3 pattern and white matter hyperintensity volume. Conclusion: Distinct nutrient biomarker patterns detected in plasma are interpretable and account for a significant degree of variance in both cognitive function and brain volume. Objective and multivariate approaches to the study of nutrition in brain health warrant further study. These findings should be confirmed in a separate population.

UR - http://www.scopus.com/inward/record.url?scp=84857738163&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857738163&partnerID=8YFLogxK

U2 - 10.1212/WNL.0b013e3182436598

DO - 10.1212/WNL.0b013e3182436598

M3 - Article

C2 - 22205763

AN - SCOPUS:84857738163

VL - 78

SP - 241

EP - 249

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 4

ER -