Nucleoprotein coated latex particles in the serologic diagnosis of systemic lupus erythematosus. A comparative clinical and serologic study

Robert (Rob) Bennett, B. Langer, E. Molina

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A commercially available test for systemic lupus erythematosus employing nucleoprotein coated latex particles was evaluated both clinically and serologically. The sera from all 40 subjects with active SLE had positive latex tests, while all 28 sera from healthy adults had negative latex tests. False positive latex tests were observed in five of 13 antinuclear factor positive patients with other chronic inflammatory diseases. Specific DNAase and RNAase digestion of the latex particles suggested the falsepositive results were due to DNA moieties, other than native DNA, coating the latex particles.

Original languageEnglish (US)
Pages (from-to)743-745
Number of pages3
JournalAmerican Journal of Clinical Pathology
Volume66
Issue number4
StatePublished - 1976
Externally publishedYes

Fingerprint

Nucleoproteins
Latex
Microspheres
Systemic Lupus Erythematosus
Deoxyribonucleases
Antinuclear Antibodies
DNA
Serum
Digestion
Chronic Disease
Clinical Studies

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Nucleoprotein coated latex particles in the serologic diagnosis of systemic lupus erythematosus. A comparative clinical and serologic study. / Bennett, Robert (Rob); Langer, B.; Molina, E.

In: American Journal of Clinical Pathology, Vol. 66, No. 4, 1976, p. 743-745.

Research output: Contribution to journalArticle

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