Nuclear magnetic resonance assessment of adenosine triphosphate (Atp) dynamics in ischemic mouse livers perfused with adenine and ribose

Robert G. Lee, Charles Springer, Paul Kasulis, Amos Lanir, Jonathan Frazer, Melvin E. Clouse

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Hepatic energy stores are essential to liver viability. We used a mouse liver perfusion model and MR spectroscopy to study the effect of adding two precursors of ATP (adenine and ribose) on ATP dynamics during ischemia and reperfusion. Using Krebs-Henseleit buffer with or without added adenine and ribose made little difference in the ATP decay rate during ischemia, but the recovery of ATP during reperfusion was more complete when adenine and ribose were added to the buffer. These findings suggest that the addition of the precursors of ATP, adenine and ribose, to perfusate after ischemia can accelerate and enhance ATP recovery.

Original languageEnglish (US)
Pages (from-to)685-687
Number of pages3
JournalInvestigative Radiology
Volume22
Issue number8
DOIs
StatePublished - Aug 1987
Externally publishedYes

Keywords

  • ATP
  • Ischemia
  • Liver
  • NMR

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Nuclear magnetic resonance assessment of adenosine triphosphate (Atp) dynamics in ischemic mouse livers perfused with adenine and ribose'. Together they form a unique fingerprint.

  • Cite this