Novel vaccine vectors for HIV.1

Dan H. Barouch, Louis J. Picker

Research output: Contribution to journalReview article

57 Scopus citations

Abstract

The ultimate solution to the global HIV.1 epidemic will probably require the development of a safe and effective vaccine. Multiple vaccine platforms have been evaluated in preclinical and clinical trials, but given the disappointing results of clinical efficacy studies so far, novel vaccine approaches are needed. In this Opinion article, we discuss the scientific basis and clinical potential of novel adenovirus and cytomegalovirus vaccine vectors for HIV.1 as two contrasting but potentially complementary vector approaches. Both of these vector platforms have demonstrated partial protection against stringent simian immunodeficiency virus challenges in rhesus monkeys using different immunological mechanisms.

Original languageEnglish (US)
Pages (from-to)765-771
Number of pages7
JournalNature Reviews Microbiology
Volume12
Issue number11
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Microbiology(all)
  • Infectious Diseases

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