Novel treatment of chronic severe hand dermatitis with bexarotene gel

Jon Hanifin, V. Stevens, P. Sheth, D. Breneman

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Background: Hand dermatitis is an eczematous inflammation of the hands that is related to occupation or to routine activities. It often becomes chronic, and in some patients may become severe and disabling. Topical corticosteroids are effective treatment, particularly for milder forms, but they often lose effectiveness with time and can produce skin atrophy. Objectives: To evaluate bexarotene gel topical therapy for safety, tolerability and efficacy in patients with chronic hand dermatitis. Methods: A phase I-II open-label randomized clinical study of bexarotene gel, alone and in combination with a low- and a mid-potency steroid, was conducted in 55 patients with chronic severe hand dermatitis at two academic clinics. Results: Patients using bexarotene gel monotherapy reached a 79% response rate for ≥50% clinical improvement and a 39% response rate for ≥90% clearance of hands. Adverse events possibly related to treatment in all patients were stinging or burning (15%), flare of dermatitis (16%) and irritation (29%). Thirteen patients (24%) withdrew early, including two for related adverse events and five for inadequate response. Conclusions: Bexarotene gel appears to be safe, tolerated by most patients, with useful therapeutic activity in chronic severe hand dermatitis.

Original languageEnglish (US)
Pages (from-to)545-553
Number of pages9
JournalBritish Journal of Dermatology
Volume150
Issue number3
DOIs
StatePublished - Mar 2004

Fingerprint

Dermatitis
Hand
Gels
Therapeutics
Eczema
bexarotene
Occupations
Atrophy
Adrenal Cortex Hormones
Steroids
Inflammation
Safety
Skin

Keywords

  • Bexarotene
  • Hand eczema
  • Irritant contact dermatitis
  • Rexinoid

ASJC Scopus subject areas

  • Dermatology

Cite this

Novel treatment of chronic severe hand dermatitis with bexarotene gel. / Hanifin, Jon; Stevens, V.; Sheth, P.; Breneman, D.

In: British Journal of Dermatology, Vol. 150, No. 3, 03.2004, p. 545-553.

Research output: Contribution to journalArticle

Hanifin, Jon ; Stevens, V. ; Sheth, P. ; Breneman, D. / Novel treatment of chronic severe hand dermatitis with bexarotene gel. In: British Journal of Dermatology. 2004 ; Vol. 150, No. 3. pp. 545-553.
@article{7bf9a0e61ac648b299bd1c2bbac70322,
title = "Novel treatment of chronic severe hand dermatitis with bexarotene gel",
abstract = "Background: Hand dermatitis is an eczematous inflammation of the hands that is related to occupation or to routine activities. It often becomes chronic, and in some patients may become severe and disabling. Topical corticosteroids are effective treatment, particularly for milder forms, but they often lose effectiveness with time and can produce skin atrophy. Objectives: To evaluate bexarotene gel topical therapy for safety, tolerability and efficacy in patients with chronic hand dermatitis. Methods: A phase I-II open-label randomized clinical study of bexarotene gel, alone and in combination with a low- and a mid-potency steroid, was conducted in 55 patients with chronic severe hand dermatitis at two academic clinics. Results: Patients using bexarotene gel monotherapy reached a 79{\%} response rate for ≥50{\%} clinical improvement and a 39{\%} response rate for ≥90{\%} clearance of hands. Adverse events possibly related to treatment in all patients were stinging or burning (15{\%}), flare of dermatitis (16{\%}) and irritation (29{\%}). Thirteen patients (24{\%}) withdrew early, including two for related adverse events and five for inadequate response. Conclusions: Bexarotene gel appears to be safe, tolerated by most patients, with useful therapeutic activity in chronic severe hand dermatitis.",
keywords = "Bexarotene, Hand eczema, Irritant contact dermatitis, Rexinoid",
author = "Jon Hanifin and V. Stevens and P. Sheth and D. Breneman",
year = "2004",
month = "3",
doi = "10.1046/j.1365-2133.2003.05729.x",
language = "English (US)",
volume = "150",
pages = "545--553",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Novel treatment of chronic severe hand dermatitis with bexarotene gel

AU - Hanifin, Jon

AU - Stevens, V.

AU - Sheth, P.

AU - Breneman, D.

PY - 2004/3

Y1 - 2004/3

N2 - Background: Hand dermatitis is an eczematous inflammation of the hands that is related to occupation or to routine activities. It often becomes chronic, and in some patients may become severe and disabling. Topical corticosteroids are effective treatment, particularly for milder forms, but they often lose effectiveness with time and can produce skin atrophy. Objectives: To evaluate bexarotene gel topical therapy for safety, tolerability and efficacy in patients with chronic hand dermatitis. Methods: A phase I-II open-label randomized clinical study of bexarotene gel, alone and in combination with a low- and a mid-potency steroid, was conducted in 55 patients with chronic severe hand dermatitis at two academic clinics. Results: Patients using bexarotene gel monotherapy reached a 79% response rate for ≥50% clinical improvement and a 39% response rate for ≥90% clearance of hands. Adverse events possibly related to treatment in all patients were stinging or burning (15%), flare of dermatitis (16%) and irritation (29%). Thirteen patients (24%) withdrew early, including two for related adverse events and five for inadequate response. Conclusions: Bexarotene gel appears to be safe, tolerated by most patients, with useful therapeutic activity in chronic severe hand dermatitis.

AB - Background: Hand dermatitis is an eczematous inflammation of the hands that is related to occupation or to routine activities. It often becomes chronic, and in some patients may become severe and disabling. Topical corticosteroids are effective treatment, particularly for milder forms, but they often lose effectiveness with time and can produce skin atrophy. Objectives: To evaluate bexarotene gel topical therapy for safety, tolerability and efficacy in patients with chronic hand dermatitis. Methods: A phase I-II open-label randomized clinical study of bexarotene gel, alone and in combination with a low- and a mid-potency steroid, was conducted in 55 patients with chronic severe hand dermatitis at two academic clinics. Results: Patients using bexarotene gel monotherapy reached a 79% response rate for ≥50% clinical improvement and a 39% response rate for ≥90% clearance of hands. Adverse events possibly related to treatment in all patients were stinging or burning (15%), flare of dermatitis (16%) and irritation (29%). Thirteen patients (24%) withdrew early, including two for related adverse events and five for inadequate response. Conclusions: Bexarotene gel appears to be safe, tolerated by most patients, with useful therapeutic activity in chronic severe hand dermatitis.

KW - Bexarotene

KW - Hand eczema

KW - Irritant contact dermatitis

KW - Rexinoid

UR - http://www.scopus.com/inward/record.url?scp=1842506669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842506669&partnerID=8YFLogxK

U2 - 10.1046/j.1365-2133.2003.05729.x

DO - 10.1046/j.1365-2133.2003.05729.x

M3 - Article

C2 - 15030340

AN - SCOPUS:1842506669

VL - 150

SP - 545

EP - 553

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 3

ER -