Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes

Nicholas J. Maness, Jonah B. Sacha, Shari M. Piaskowski, Kimberly L. Weisgrau, Eva G. Rakasz, Gemma E. May, Matthew B. Buechler, Andrew D. Walsh, Nancy A. Wilson, David I. Watkins

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Understanding the correlates of immune protection against human immunodeficiency virus and simian immunodeficiency virus (SIV) will require defining the entire cellular immune response against the viruses. Here, we define two novel translation products from the SIV env mRNA that are targeted by the T-cell response in SIV-infected rhesus macaques. The shorter product is a subset of the larger product, which contains both the first exon of the Rev protein and a translated portion of the rev intron. Our data suggest that the translation of viral alternate reading frames may be an important source of T-cell epitopes, including epitopes normally derived from functional proteins.

Original languageEnglish (US)
Pages (from-to)10280-10285
Number of pages6
JournalJournal of virology
Volume83
Issue number19
DOIs
StatePublished - Oct 2009

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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