Abstract
(Matrix presented) Two novel sulfur-containing analogs of the immunosuppressive natural product rapamycin (1) were obtained by feeding cultures of Streptomyces hygroscopicus with L-nipecotic acid (4) and either (S)-1,3-thiazane-4-carboxylic acid (5) or (S)-1,4-thiazane-3-carboxylic acid (6). The structures of the two new compounds, 20-thiarapamycin (2) and 15-deoxo-19-sulfoxylrapamycin (3), were determined by spectroscopic methods.
Original language | English (US) |
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Pages (from-to) | 2385-2388 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 5 |
Issue number | 14 |
DOIs | |
State | Published - Jul 10 2003 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry