Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns

Mary L. Arcila, Marion Betizeau, Xiaolu A. Cambronne, Elmer Guzman, Nathalie Doerflinger, Frantz Bouhallier, Hongjun Zhou, Bian Wu, Neha Rani, Danielle S. Bassett, Ugo Borello, Cyril Huissoud, Richard H. Goodman, Colette Dehay, Kenneth S. Kosik

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Major nonprimate-primate differences in corticogenesis include the dimensions, precursor lineages, and developmental timing of the germinal zones (GZs). microRNAs (miRNAs) of laser-dissected GZ compartments and cortical plate (CP) from embryonic E80 macaque visual cortex were deep sequenced. The CP and the GZ including ventricular zone (VZ) and outer and inner subcompartments of the outer subventricular zone (OSVZ) in area 17 displayed unique miRNA profiles. miRNAs present in primate, but absent in rodent, contributed disproportionately to the differential expression between GZ subregions. Prominent among the validated targets of these miRNAs were cell-cycle and neurogenesis regulators. Coevolution between the emergent miRNAs and their targets suggested that novel miRNAs became integrated into ancient gene circuitry to exert additional control over proliferation. We conclude that multiple cell-cycle regulatory events contribute to the emergence of primate-specific cortical features, including the OSVZ, generated enlarged supragranular layers, largely responsible for the increased primate cortex computational abilities.

Original languageEnglish (US)
Pages (from-to)1255-1262
Number of pages8
JournalNeuron
Volume81
Issue number6
DOIs
StatePublished - Mar 19 2014

ASJC Scopus subject areas

  • Neuroscience(all)

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    Arcila, M. L., Betizeau, M., Cambronne, X. A., Guzman, E., Doerflinger, N., Bouhallier, F., Zhou, H., Wu, B., Rani, N., Bassett, D. S., Borello, U., Huissoud, C., Goodman, R. H., Dehay, C., & Kosik, K. S. (2014). Novel primate miRNAs coevolved with ancient target genes in germinal zone-specific expression patterns. Neuron, 81(6), 1255-1262. https://doi.org/10.1016/j.neuron.2014.01.017