Novel pharmacotherapy for fibromyalgia

Patrick B. Wood, Andrew J. Holman, Kim D. Jones

    Research output: Contribution to journalReview article

    22 Scopus citations

    Abstract

    Fibromyalgia is a common disorder that is characterized by chronic wide-spread pain, tenderness to light palpation, fatigue and sleep disturbances. The present lack of a well-accepted model of the disorder has hampered progress towards adequate treatment. A review of potential models to explain the pathophysiology underlying its primary symptom (i.e., chronic widespread pain) lends insight on the therapeutic potential of novel therapies. Following this, a mechanistic evaluation of those medications that are under consideration for the treatment of the disorder is offered. Adequate treatment will be likely to involve the identification of biologic sub-groups within the greater fibromyalgia construct. Key insights from basic research are the basis for increased optimism for effective relief among patients and clinicians.

    Original languageEnglish (US)
    Pages (from-to)829-841
    Number of pages13
    JournalExpert Opinion on Investigational Drugs
    Volume16
    Issue number6
    DOIs
    StatePublished - Jun 1 2007

    Keywords

    • Central sensitization
    • Chronic widespread pain
    • Descending inhibition
    • Dopamine
    • Fibromyalgia

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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