Novel oral detoxification of mercury, cadmium, and lead with thiol-modified nanoporous silica

Thanapon Sangvanich, Jingga Morry, Cade Fox, Worapol Ngamcherdtrakul, Shaun Goodyear, David Castro, Glen E. Fryxell, Raymond S. Addleman, Anne O. Summers, Wassana Yantasee

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We have developed a thiol-modified nanoporous silica material (SH-SAMMS) as an oral therapy for the prevention and treatment of heavy metal poisoning. SH-SAMMS has been reported to be highly efficient at capturing heavy metals in biological fluids and water. Herein, SH-SAMMS was examined for efficacy and safety in both in vitro and in vivo animal models for the oral detoxification of heavy metals. In simulated gastrointestinal fluids, SH-SAMMS had a very high affinity (Kd) for methyl mercury (MeHg(I)), inorganic mercury (Hg(II)), lead (Pb(II)), and cadmium (Cd(II)) and was superior to other SAMMS with carboxylic acid or phosphonic acid ligands or commercially available metal chelating sorbents. SH-SAMMS also effectively removed Hg from biologically digested fish tissue with no effect on most nutritional minerals found in fish. SH-SAMMS could hold Hg(II) and MeHg(I) tightly inside the nanosize pores, thus preventing bacteria from converting them to more absorbable forms. Rats fed a diet containing MeHg(I), Cd(II), and Pb(II) and SH-SAMMS for 2 weeks had blood Hg levels significantly lower than rats fed the metal-rich diet only. Upon cessation of the metal-rich diet, continued administration of SH-SAMMS for 2 weeks facilitated faster and more extensive clearance of Hg than in animals not continued on oral SH-SAMMS. Rats receiving SH-SAMMS also suffered less weight loss as a result of the metal exposure. Retention of Hg and Cd in major organs was lowest in rats fed with SH-SAMMS throughout the entire four weeks. The reduction of blood Pb by SH-SAMMS was significant. SH-SAMMS was safe to intestinal epithelium model (Caco-2) and common intestinal bacteria (Escherichia coli). Altogether, it has great potential as a new oral drug for the treatment of heavy metal poisoning. This new application is enabled by the installation of tailored interfacial chemistry upon nontoxic nanoporous materials.

Original languageEnglish (US)
Pages (from-to)5483-5493
Number of pages11
JournalACS Applied Materials and Interfaces
Volume6
Issue number8
DOIs
StatePublished - Apr 23 2014

Keywords

  • cadmium
  • chelation therapy
  • detoxification
  • lead
  • mercury
  • mesoporous silica
  • nanoporous
  • thiol

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Sangvanich, T., Morry, J., Fox, C., Ngamcherdtrakul, W., Goodyear, S., Castro, D., Fryxell, G. E., Addleman, R. S., Summers, A. O., & Yantasee, W. (2014). Novel oral detoxification of mercury, cadmium, and lead with thiol-modified nanoporous silica. ACS Applied Materials and Interfaces, 6(8), 5483-5493. https://doi.org/10.1021/am5007707