Novel object recognition in Apoe-/- mice improved by neonatal implantation of wild-type multipotential stromal cells

Alexandra Peister, Suzanne Zeitouni, Timothy Pfankuch, Roxanne L. Reger, Darwin J. Prockop, Jacob Raber

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe-/-) mice were implanted into the cerebral ventricles of Apoe-/- mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
JournalExperimental Neurology
Volume201
Issue number1
DOIs
StatePublished - Sep 1 2006

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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