Novel object recognition in Apoe-/- mice improved by neonatal implantation of wild-type multipotential stromal cells

Alexandra Peister, Suzanne Zeitouni, Timothy Pfankuch, Roxanne L. Reger, Darwin J. Prockop, Jacob Raber

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe-/-) mice were implanted into the cerebral ventricles of Apoe-/- mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)266-269
Number of pages4
JournalExperimental Neurology
Volume201
Issue number1
DOIs
StatePublished - Sep 2006

Fingerprint

Apolipoproteins E
Stromal Cells
Bone Marrow
Cerebral Ventricles
Gene Knockout Techniques
Microtubule-Associated Proteins
Dentate Gyrus
Mesenchymal Stromal Cells
Neurodegenerative Diseases
Therapeutics

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

Cite this

Novel object recognition in Apoe-/- mice improved by neonatal implantation of wild-type multipotential stromal cells. / Peister, Alexandra; Zeitouni, Suzanne; Pfankuch, Timothy; Reger, Roxanne L.; Prockop, Darwin J.; Raber, Jacob.

In: Experimental Neurology, Vol. 201, No. 1, 09.2006, p. 266-269.

Research output: Contribution to journalArticle

Peister, Alexandra ; Zeitouni, Suzanne ; Pfankuch, Timothy ; Reger, Roxanne L. ; Prockop, Darwin J. ; Raber, Jacob. / Novel object recognition in Apoe-/- mice improved by neonatal implantation of wild-type multipotential stromal cells. In: Experimental Neurology. 2006 ; Vol. 201, No. 1. pp. 266-269.
@article{46818387319e4c4dbe8defdc30a6e6fa,
title = "Novel object recognition in Apoe-/- mice improved by neonatal implantation of wild-type multipotential stromal cells",
abstract = "Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe-/-) mice were implanted into the cerebral ventricles of Apoe-/- mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.",
author = "Alexandra Peister and Suzanne Zeitouni and Timothy Pfankuch and Reger, {Roxanne L.} and Prockop, {Darwin J.} and Jacob Raber",
year = "2006",
month = "9",
doi = "10.1016/j.expneurol.2006.03.023",
language = "English (US)",
volume = "201",
pages = "266--269",
journal = "Experimental Neurology",
issn = "0014-4886",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Novel object recognition in Apoe-/- mice improved by neonatal implantation of wild-type multipotential stromal cells

AU - Peister, Alexandra

AU - Zeitouni, Suzanne

AU - Pfankuch, Timothy

AU - Reger, Roxanne L.

AU - Prockop, Darwin J.

AU - Raber, Jacob

PY - 2006/9

Y1 - 2006/9

N2 - Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe-/-) mice were implanted into the cerebral ventricles of Apoe-/- mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.

AB - Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe-/-) mice were implanted into the cerebral ventricles of Apoe-/- mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.

UR - http://www.scopus.com/inward/record.url?scp=33747354631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747354631&partnerID=8YFLogxK

U2 - 10.1016/j.expneurol.2006.03.023

DO - 10.1016/j.expneurol.2006.03.023

M3 - Article

C2 - 16808914

AN - SCOPUS:33747354631

VL - 201

SP - 266

EP - 269

JO - Experimental Neurology

JF - Experimental Neurology

SN - 0014-4886

IS - 1

ER -