Abstract
Multipotential bone marrow stromal cells (MSCs) from wild-type (Wt) or apolipoprotein E deficient (Apoe-/-) mice were implanted into the cerebral ventricles of Apoe-/- mice. MSCs from Wt mice continued expressing apoE up to 6 months after implantation and were associated with enhanced novel object recognition and increased microtubule-associated protein 2 (MAP2) immunoreactivity in the dentate gyrus. These data show that MSCs can be used to distinguish developmental from post-developmental effects of a gene knockout and support their therapeutic potential for neurodegenerative diseases.
Original language | English (US) |
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Pages (from-to) | 266-269 |
Number of pages | 4 |
Journal | Experimental Neurology |
Volume | 201 |
Issue number | 1 |
DOIs | |
State | Published - Sep 2006 |
ASJC Scopus subject areas
- Neurology
- Developmental Neuroscience