Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

M. N. Hanson, L. C. Preheim, S. Chou, C. L. Talarico, K. K. Biron, A. Erice

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Abstract

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

Original languageEnglish (US)
Pages (from-to)1204-1205
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume39
Issue number5
DOIs
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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