Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

M. N. Hanson; L. C. Preheim; S. Chou; C. L. Talarico; K. K. Biron; A. Erice

doi:10.1128/AAC.39.5.1204

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

M. N. Hanson, L. C. Preheim, S. Chou, C. L. Talarico, K. K. Biron, A. Erice

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

Original language	English (US)
Pages (from-to)	1204-1205
Number of pages	2
Journal	Antimicrobial agents and chemotherapy
Volume	39
Issue number	5
DOIs	https://doi.org/10.1128/AAC.39.5.1204
State	Published - 1995
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.39.5.1204

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abstract = "Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.",

author = "Hanson, {M. N.} and Preheim, {L. C.} and S. Chou and Talarico, {C. L.} and Biron, {K. K.} and A. Erice",

year = "1995",

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T1 - Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

AU - Hanson, M. N.

AU - Preheim, L. C.

AU - Chou, S.

AU - Talarico, C. L.

AU - Biron, K. K.

AU - Erice, A.

PY - 1995

Y1 - 1995

N2 - Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

AB - Characterization of a ganciclovir-resistant cytomegalovirus strain from a patient with AIDS showed a histidine-to-glutamine change at residue 520 of UL97 (Q520 mutation). In anabolism studies, Q520 was associated with impaired phosphorylation of ganciclovir. Transfer of Q520 to a recombinant virus resulted in a ganciclovir-resistant phenotype.

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ER -

Novel mutation in the UL97 gene of a clinical cytomegalovirus strain conferring resistance to ganciclovir

Abstract

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