Novel Imaging Methods for Analysis of Tissue Resident Cells in HIV/SIV

Eirini Moysi, Jacob D. Estes, Constantinos Petrovas

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The use of advanced tissue-imaging methodologies has greatly facilitated the study of molecular mechanisms and cellular interactions in humans and animal models of disease. Particularly, in HIV research, there is an ever-increasing demand for a comprehensive analysis of immune cell dynamics at tissue level stemming from the need to advance our understanding of those interactions that regulate the generation of adaptive antigen-specific immune responses. The latter is critical for the development of vaccines to elicit broadly neutralizing antibodies as well as for the discovery of novel targets for immuno-therapies to strengthen the cytolytic arm of the immune system at local level. In this review, we focus on current and emerging imaging technologies, discuss their strengths and limitations, and examine how such technologies can inform the development of new treatments and vaccination strategies. We also present some perspective on the future of the technology development.

Original languageEnglish (US)
Pages (from-to)38-43
Number of pages6
JournalCurrent HIV/AIDS Reports
Volume13
Issue number1
DOIs
StatePublished - Feb 1 2016

Keywords

  • HIV
  • HIV pathogenesis
  • Imaging
  • Review
  • SIV
  • Tissues

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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