Novel features of G protein-coupled receptor kinase 4

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Abstract

The defining characteristic of G protein-coupled receptor homologous desensitization is that the receptor must be occupied by an agonist or in an activated conformation that mimics an agonist-induced state. In most instances, the mechanistic basis for this characteristic is the high selectivity of G protein-coupled receptor kinases for the activated receptor. In this issue, Rankin et al. (p. 759) demonstrate that under some conditions, at least, the G protein-coupled receptor kinase GRK4 does not display a preference for the agonist-occupied D1 dopamine receptor. Coexpression of GRK4 and the D1 receptor in a heterologous system induces phosphorylation of the receptor in the absence of agonist, causing constitutive desensitization and internalization of the receptor. Lacking the normal rapid feedback mechanisms associated with homologous desensitization, a system incorporating constitutively active GRK4 will be prone to dysregulation, perhaps explaining the generally low expression of GRK4. Indeed, considerable evidence suggests that just such dysregulation resulting from mutationally activated GRK4 contributes to the heritable component of human essential hypertension.

Original languageEnglish (US)
Pages (from-to)673-676
Number of pages4
JournalMolecular Pharmacology
Volume69
Issue number3
DOIs
StatePublished - Mar 2006

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G-Protein-Coupled Receptor Kinase 4
G-Protein-Coupled Receptor Kinases
Dopamine D1 Receptors
G-Protein-Coupled Receptors
Phosphorylation

ASJC Scopus subject areas

  • Pharmacology

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Novel features of G protein-coupled receptor kinase 4. / Neve, Kim.

In: Molecular Pharmacology, Vol. 69, No. 3, 03.2006, p. 673-676.

Research output: Contribution to journalArticle

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