Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat

Lori K. Singer, Joel Kuper, Rebecca S. Brogan, M (Susan) Smith, Kevin Grove

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    35 Scopus citations

    Abstract

    Neuropeptide Y (NPY) is a potent orexigenic peptide. In the normal adult rat, hypothalamic NPY mRNA expression is limited to the arcuate nucleus (ARH). The purposes of this study was to characterize the developmental expression of NPY mRNA in the hypothalamus of the rat. In contrast to the normal adult rat, NPY mRNA was observed in the ARH, the dorsomedial hypothalamic nucleus (DMH) and the perifornical region (PFR) during development. NPY mRNA expression in all three regions increased progressively from postnatal days 0-4 (P0-4) to reach maximum levels at P16 and subsequently decreased to near adult levels by P30. The unique expression of NPY mRNA in the PFR and DMH may be important in establishing the proper management of energy homeostasis and body weight in the adult animal. (C) 2000 Lippincott Williams and Wilkins.

    Original languageEnglish (US)
    Pages (from-to)1075-1080
    Number of pages6
    JournalNeuroReport
    Volume11
    Issue number5
    Publication statusPublished - Apr 7 2000

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    Keywords

    • Food intake
    • Hypothalamus
    • In situ hybridization
    • Neuropeptide Y
    • Perifornical region
    • Postnatal development

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Singer, L. K., Kuper, J., Brogan, R. S., Smith, M. S., & Grove, K. (2000). Novel expression of hypothalamic neuropeptide Y during postnatal development in the rat. NeuroReport, 11(5), 1075-1080.