Novel 3,5-bis(arylidiene)-4-piperidone based monocarbonyl analogs of curcumin: Anticancer activity evaluation and mode of action study

Anuj Thakur, Sunny Manohar, Christian E. Vélez Gerena, Beatriz Zayas, Vineet Kumar, Sanjay V. Malhotra, Diwan S. Rawat

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A series of eighteen novel 3,5-bis(arylidiene)-4-piperidone based symmetrical monocarbonyl analogs of curcumin were synthesised and a subset was screened by National Cancer Institute (NCI), USA for their anticancer activity. Dose-response studies and the mechanism of action investigation suggest that most active compounds are apoptosis inducers. This journal is

Original languageEnglish (US)
Pages (from-to)576-586
Number of pages11
JournalMedChemComm
Volume5
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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