Notch receptor activation inhibits oligodendrocyte differentiation

Songli Wang, Andrei D. Sdrulla, Guy DiSibio, Gay Bush, Donna Nofziger, Carol Hicks, Gerry Weinmaster, Ben A. Barres

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Abstract

In this study, we show that oligodendrocyte differentiation is powerfully inhibited by activation of the Notch pathway. Oligodendrocytes and their precursors in the developing rat optic nerve express Notch1 receptors and, at the same time, retinal ganglion cells express Jagged1, a ligand of the Notch1 receptor, along their axons. Jagged1 expression is developmentally regulated, decreasing with a time course that parallels myelination in the optic nerve. These results suggest that the timing of oligodendrocyte differentiation and myelination is controlled by the Notch pathway and raise the question of whether localization of myelination is controlled by this pathway.

Original languageEnglish (US)
Pages (from-to)63-75
Number of pages13
JournalNeuron
Volume21
Issue number1
DOIs
StatePublished - Jul 1998

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Wang, S., Sdrulla, A. D., DiSibio, G., Bush, G., Nofziger, D., Hicks, C., Weinmaster, G., & Barres, B. A. (1998). Notch receptor activation inhibits oligodendrocyte differentiation. Neuron, 21(1), 63-75. https://doi.org/10.1016/S0896-6273(00)80515-2