Not all cytokine-producing CD8+ T cells suppress simian immunodeficiency virus replication

Won Chung, Wonhee Lee, John T. Loffredo, Benjamin Burwitz, Thomas C. Friedrich, Juan Pablo Giraldo Vela, Gnankang Napoe, Eva G. Rakasz, Nancy A. Wilson, David B. Allison, David I. Watkins

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Current assays of CD8+ T-lymphocyte function measure cytokine production rather than the ability of these lymphocytes to suppress viral replication. Here we show that CD8+ T-cell clones recognizing the same epitope vary enormously in the ability to suppress simian immunodeficiency virus SIVmac239 replication in an in vitro suppression assay. However, all Nef 165-173IW9- and Vif66-73HW8-speciflc clones from elite controllers effectively suppressed SIV replication. Interestingly, in vitro suppression efficacy was not always associated with the ability to produce gamma interferon, tumor necrosis factor alpha, or interleukin-2.

Original languageEnglish (US)
Pages (from-to)1517-1523
Number of pages7
JournalJournal of virology
Volume81
Issue number3
DOIs
StatePublished - Feb 2007

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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