Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency

G. L. Stanley, M. A. Pfaller, M. Mori, R. P. Wenzel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC90 range: 0·06-0·5 μg ml-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalJournal of Hospital Infection
Volume14
Issue number3
DOIs
StatePublished - Oct 1989

Keywords

  • Nosocomial bacteraemia
  • antibiotics
  • beta-lactamase

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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