Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency

G. L. Stanley, M. A. Pfaller, Motomi (Tomi) Mori, R. P. Wenzel

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC90 range: 0·06-0·5 μg ml-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.

Original languageEnglish (US)
Pages (from-to)217-225
Number of pages9
JournalJournal of Hospital Infection
Volume14
Issue number3
DOIs
StatePublished - 1989
Externally publishedYes

Fingerprint

Anti-Bacterial Agents
beta-Lactamases
Ciprofloxacin
Cross Infection
Bacteremia
Hospitalization
Morbidity
Mortality
In Vitro Techniques

Keywords

  • antibiotics
  • beta-lactamase
  • Nosocomial bacteraemia

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

Cite this

Nosocomial gram-negative bloodstream isolates : a comparison of in vitro antibiotic potency. / Stanley, G. L.; Pfaller, M. A.; Mori, Motomi (Tomi); Wenzel, R. P.

In: Journal of Hospital Infection, Vol. 14, No. 3, 1989, p. 217-225.

Research output: Contribution to journalArticle

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