Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency

G. L. Stanley; M. A. Pfaller; M. Mori; R. P. Wenzel

doi:10.1016/0195-6701(89)90038-8

Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency

G. L. Stanley, M. A. Pfaller, M. Mori, R. P. Wenzel

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC₉₀ range: 0·06-0·5 μg ml^-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.

Original language	English (US)
Pages (from-to)	217-225
Number of pages	9
Journal	Journal of Hospital Infection
Volume	14
Issue number	3
DOIs	https://doi.org/10.1016/0195-6701(89)90038-8
State	Published - Oct 1989

Keywords

Nosocomial bacteraemia
antibiotics
beta-lactamase

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/0195-6701(89)90038-8

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abstract = "Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC90 range: 0·06-0·5 μg ml-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.",

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AU - Pfaller, M. A.

AU - Mori, M.

AU - Wenzel, R. P.

PY - 1989/10

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AB - Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC90 range: 0·06-0·5 μg ml-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.

KW - Nosocomial bacteraemia

KW - antibiotics

KW - beta-lactamase

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Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency

Abstract

Keywords

ASJC Scopus subject areas

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