Nosocomial gram-negative bloodstream isolates: a comparison of in vitro antibiotic potency

G. L. Stanley, M. A. Pfaller, M. Mori, R. P. Wenzel

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations

    Abstract

    Nosocomial bloodstream infections add to the morbidity, mortality and length of hospitalization that is attributed to the underlying diseases alone. We have compared the in vitro potency of fifteen antibiotics against 136 isolates from clinically significant nosocomial gram-negative bacteraemias. Ciprofloxacin was the most potent antibiotic and had the broadest spectrum of activity (98% of isolates susceptible, MIC90 range: 0·06-0·5 μg ml-1). We subjected all isolates to beta-lactamase induction but antibiotic susceptibility was unaffected by this procedure.

    Original languageEnglish (US)
    Pages (from-to)217-225
    Number of pages9
    JournalJournal of Hospital Infection
    Volume14
    Issue number3
    DOIs
    StatePublished - Oct 1989

    Keywords

    • Nosocomial bacteraemia
    • antibiotics
    • beta-lactamase

    ASJC Scopus subject areas

    • Microbiology (medical)
    • Infectious Diseases

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