TY - JOUR
T1 - North American Contact Dermatitis Group patch test results
T2 - 2009 to 2010
AU - Warshaw, Erin M.
AU - Belsito, Donald V.
AU - Taylor, James S.
AU - Sasseville, Denis
AU - DeKoven, Joel G.
AU - Zirwas, Matthew J.
AU - Fransway, Anthony F.
AU - Mathias, C. G.Toby
AU - Zug, Kathryn A.
AU - DeLeo, Vincent A.
AU - Fowler, Joseph F.
AU - Marks, James G.
AU - Pratt, Melanie D.
AU - Storrs, Frances J.
AU - Maibach, Howard I.
PY - 2013
Y1 - 2013
N2 - Background: Patch testing is an important diagnostic tool for determination of substances responsible for allergic contact dermatitis. Objective: This study reports the North American Contact Dermatitis Group (NACDG) patch testing results from January 1, 2009, to December 31, 2010. Methods: At 12 centers in North America, patients were tested in a standardized manner with a screening series of 70 allergens. Data were manually verified and entered into a central database. Descriptive frequencies were calculated, and trends were analyzed using χ2 statistics. Results: A total of 4308 patients were tested. Of these, 2614 (60.7%) had at least 1 positive reaction, and 2284 (46.3%) were ultimately determined to have a primary diagnosis of allergic contact dermatitis. Four hundred twenty-seven (9.9%) patients had occupationally related skin disease. There were 6855 positive allergic reactions. As compared with the previous reporting period (2007-2008), the positive reaction rates statistically decreased for 20 allergens (nickel, neomycin, Myroxylon pereirae, cobalt, formaldehyde, quaternium 15, methydibromoglutaronitrile/phenoxyethanol, methylchlorisothiazolinone/methylisothiazolinone, potassium dichromate, diazolidinyl urea, propolis, dimethylol dimethylhydantoin, 2-bromo-2-nitro-1,3- propanediol, methyl methacrylate, ethyl acrylate, glyceryl thioglycolate, dibucaine, amidoamine, clobetasol, and dimethyloldihydroxyethyleneurea; P < 0.05) and statistically increased for 4 allergens (fragrance mix II, iodopropynyl butylcarbamate, propylene glycol, and benzocaine; P < 0.05). Approximately one quarter of tested patients had at least 1 relevant allergic reaction to a non-NACDG allergen. Hypothetically, approximately one quarter of reactions detected by NACDG allergens would have been missed by TRUE TEST (Smart Practice Denmark, Hillerød, Denmark). Conclusions: These results affirm the value of patch testing with many allergens.
AB - Background: Patch testing is an important diagnostic tool for determination of substances responsible for allergic contact dermatitis. Objective: This study reports the North American Contact Dermatitis Group (NACDG) patch testing results from January 1, 2009, to December 31, 2010. Methods: At 12 centers in North America, patients were tested in a standardized manner with a screening series of 70 allergens. Data were manually verified and entered into a central database. Descriptive frequencies were calculated, and trends were analyzed using χ2 statistics. Results: A total of 4308 patients were tested. Of these, 2614 (60.7%) had at least 1 positive reaction, and 2284 (46.3%) were ultimately determined to have a primary diagnosis of allergic contact dermatitis. Four hundred twenty-seven (9.9%) patients had occupationally related skin disease. There were 6855 positive allergic reactions. As compared with the previous reporting period (2007-2008), the positive reaction rates statistically decreased for 20 allergens (nickel, neomycin, Myroxylon pereirae, cobalt, formaldehyde, quaternium 15, methydibromoglutaronitrile/phenoxyethanol, methylchlorisothiazolinone/methylisothiazolinone, potassium dichromate, diazolidinyl urea, propolis, dimethylol dimethylhydantoin, 2-bromo-2-nitro-1,3- propanediol, methyl methacrylate, ethyl acrylate, glyceryl thioglycolate, dibucaine, amidoamine, clobetasol, and dimethyloldihydroxyethyleneurea; P < 0.05) and statistically increased for 4 allergens (fragrance mix II, iodopropynyl butylcarbamate, propylene glycol, and benzocaine; P < 0.05). Approximately one quarter of tested patients had at least 1 relevant allergic reaction to a non-NACDG allergen. Hypothetically, approximately one quarter of reactions detected by NACDG allergens would have been missed by TRUE TEST (Smart Practice Denmark, Hillerød, Denmark). Conclusions: These results affirm the value of patch testing with many allergens.
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U2 - 10.1097/DER.0b013e3182819c51
DO - 10.1097/DER.0b013e3182819c51
M3 - Article
C2 - 23474444
AN - SCOPUS:84876214556
SN - 1710-3568
VL - 24
SP - 50
EP - 59
JO - Dermatitis
JF - Dermatitis
IS - 2
ER -