TY - JOUR
T1 - North American Contact Dermatitis Group patch-test results, 2003-2004 study period
AU - Warshaw, Erin M.
AU - Belsito, Donald V.
AU - DeLeo, Vincent A.
AU - Fowler, Joseph F.
AU - Maibach, Howard I.
AU - Marks, James G.
AU - Mathias, C. G.Toby
AU - Pratt, Melanie D.
AU - Rietschel, Robert L.
AU - Sasseville, Denis
AU - Storrs, Frances J.
AU - Taylor, James S.
AU - Zug, Kathryn A.
PY - 2008/5
Y1 - 2008/5
N2 - Background: Allergic contact dermatitis is a significant cause of both occupational and non-occupational skin disease. Patch testing is an important diagnostic tool for the determination of responsible allergens. Objective: This study reports the results of patch testing by the North American Contact Dermatitis Group from January 1, 2003, to December 31, 2004. Methods: At 13 centers in North America, patients were tested with the same screening series of 65 allergens, with a standardized patch-testing technique. Data were recorded on standardized forms and manually verified and entered. Descriptive frequencies were calculated, and trends were analyzed with chi-square statistics. Results: A total of 5,148 patients were tested. Of these, 3,432 (66.7%) had at least one positive reaction, 2,284 (44.4%) were ultimately determined to have primary allergic contact dermatitis, and 676 (13.1%) had occupation-related skin disease. There were 9,762 positive allergic reactions. Compared to the previous reporting period (2001-2002), allergies to nickel, budesonide, mercaptobenzothiazole, and paraben mix were at least 1.12 times more common (all p values < .03). Compared with the previous 8 years (1994-2002), only the prevalence rates of allergies to nickel and budesonide were statistically significantly higher (p values < .003). Conclusion: Allergic contact dermatitis from nickel and budesonide may be increasing in North America. These results again underscore the value of patch-testing with many allergens.
AB - Background: Allergic contact dermatitis is a significant cause of both occupational and non-occupational skin disease. Patch testing is an important diagnostic tool for the determination of responsible allergens. Objective: This study reports the results of patch testing by the North American Contact Dermatitis Group from January 1, 2003, to December 31, 2004. Methods: At 13 centers in North America, patients were tested with the same screening series of 65 allergens, with a standardized patch-testing technique. Data were recorded on standardized forms and manually verified and entered. Descriptive frequencies were calculated, and trends were analyzed with chi-square statistics. Results: A total of 5,148 patients were tested. Of these, 3,432 (66.7%) had at least one positive reaction, 2,284 (44.4%) were ultimately determined to have primary allergic contact dermatitis, and 676 (13.1%) had occupation-related skin disease. There were 9,762 positive allergic reactions. Compared to the previous reporting period (2001-2002), allergies to nickel, budesonide, mercaptobenzothiazole, and paraben mix were at least 1.12 times more common (all p values < .03). Compared with the previous 8 years (1994-2002), only the prevalence rates of allergies to nickel and budesonide were statistically significantly higher (p values < .003). Conclusion: Allergic contact dermatitis from nickel and budesonide may be increasing in North America. These results again underscore the value of patch-testing with many allergens.
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U2 - 10.2310/6620.2007.06060
DO - 10.2310/6620.2007.06060
M3 - Article
C2 - 18627684
AN - SCOPUS:38149109568
SN - 1710-3568
VL - 19
SP - 129
EP - 136
JO - Dermatitis
JF - Dermatitis
IS - 3
ER -